All Phenotypes Hoxc11<tm1Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxc11^tm1Mrc
targeted mutation 1, Mario R Capecchi
MGI:3526571

Summary

13 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hoxa11^tm1Dmwe/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	MGI:3814866
cx2	Hoxa11^tm1Ssp/Hoxa11^tm1Ssp Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S2/SvPas * 129S7/SvEvBrd	MGI:3844345
cx3	Hoxa11^tm1Ssp/Hoxa11^tm1Ssp Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S2/SvPas * 129S7/SvEvBrd	MGI:3844346
cx4	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S7/SvEvBrd	MGI:3814873
cx5	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3814874
cx6	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3814876
cx7	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3814878
cx8	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3814879
cx9	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3814881
cx10	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S7/SvEvBrd	MGI:3814882
cx11	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S7/SvEvBrd	MGI:3814871
cx12	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S7/SvEvBrd	MGI:3814872
cx13	Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	Not Specified	MGI:3814877

Allelic Composition	Hoxa11^tm1Dmwe/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Dmwe mutation (1 available); any Hoxa11 mutation (11 available)
Hoxc11^tm1Mrc mutation (0 available); any Hoxc11 mutation (14 available)
Hoxd11^tm1Mrc mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:140709 )

male infertility ( J:140709 )

Allelic Composition	Hoxa11^tm1Ssp/Hoxa11^tm1Ssp Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Ssp mutation (0 available); any Hoxa11 mutation (11 available)
Hoxc11^tm1Mrc mutation (0 available); any Hoxc11 mutation (14 available)
Hoxd11^tm1Mrc mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:84456 )

N	• despite altered vertebral identity, the number of vertebrae is normal

abnormal pelvic girdle bone morphology ( J:84456 )

absent sacral vertebrae ( J:84456 )

sacral vertebral transformation ( J:84456 , J:124112 )

• sacral vertebrae adopt lumbar vertebra morphologies (J:84456)

• the sacral region is lumbar-like (J:124112)

limbs/digits/tail

abnormal forelimb zeugopod morphology ( J:84456 )

abnormal hindlimb zeugopod morphology ( J:84456 )

Allelic Composition	Hoxa11^tm1Ssp/Hoxa11^tm1Ssp Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal sacral vertebrae morphology ( J:84456 )

• anterior sacral vertebrae lack sacral wings unlike in wild-type mice

• however, posterior sacral elements possess sacral wings

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Mrc mutation (0 available); any Hoxa11 mutation (11 available)
Hoxc11^tm1Mrc mutation (0 available); any Hoxc11 mutation (14 available)
Hoxd11^tm1Mrc mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:88686 )

• show reproductive defects similar to those of mice homozygous for Hoxa11^tm1Mrc

female infertility ( J:88686 )

male infertility ( J:88686 )

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:88686 )

• show reproductive defects similar to those of mice homozygous for Hoxa11^tm1Mrc

female infertility ( J:88686 )

male infertility ( J:88686 )

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney development ( J:88686 )

• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme

• absence of metanephric kidney development at E13.5 and birth

increased metanephric mesenchyme apoptosis ( J:88686 )

• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme

absent metanephros ( J:88686 )

• absence of metanephric kidney development at E13.5 and birth

absent ureteric bud ( J:88686 )

• absence of bud formation at E11.5

cellular

increased metanephric mesenchyme apoptosis ( J:88686 )

• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme

embryo

increased metanephric mesenchyme apoptosis ( J:88686 )

• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:88686 )

• bilateral kidney hypoplasia that is less severe than in Hoxa11^tm1Mrc Hoxd11^tm1Mrc double homozygotes

single kidney ( J:88686 )

• occasionally seen

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:88686 )

• hypoplasia is more severe than in mice with 4 mutant alleles

ectopic kidney ( J:88686 )

• kidneys, when present, are in a more caudal and ventral location

single kidney ( J:88686 )

• occasionally seen

• more frequent than in mice with 4 mutant alleles

abnormal ureteric bud invasion ( J:88686 )

• at E11.5, the bud forms but frequently migrates away from the metanephric mesenchyme

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:88686 )

• hypoplasia is more severe than in mice with 4 mutant alleles

ectopic kidney ( J:88686 )

• kidneys, when present, are in a more caudal and ventral location

single kidney ( J:88686 )

• occasionally seen

• more frequent than in mice with 4 mutant alleles

abnormal ureteric bud invasion ( J:88686 )

• at E11.5, the bud forms but frequently migrates away from the metanephric mesenchyme

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:88686 )

• hypoplasia is more severe than in mice with 4 mutant alleles

ectopic kidney ( J:88686 )

• kidneys, when present, are in a more caudal and ventral location

single kidney ( J:88686 )

• occasionally seen

• more frequent than in mice with 4 mutant alleles

abnormal ureteric bud invasion ( J:88686 )

• at E11.5, the bud forms but frequently migrates away from the metanephric mesenchyme

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:88686 )

• show reproductive defects similar to those of mice homozygous for Hoxa11^tm1Mrc

female infertility ( J:88686 )

male infertility ( J:88686 )

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:88686 )

• show reproductive defects similar to those of mice homozygous for Hoxa11^tm1Mrc

female infertility ( J:88686 )

male infertility ( J:88686 )

Allelic Composition	Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxc11^tm1Mrc mutation (0 available); any Hoxc11 mutation (14 available)
Hoxd11^tm1Mrc mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:88686 )

• bilateral kidney hypoplasia that is less severe than in Hoxa11^tm1Mrc Hoxd11^tm1Mrc double homozygotes

single kidney ( J:88686 )

• occasionally seen

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