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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wnt9btm1.1Amc
targeted mutation 1.1, Andrew P McMahon
MGI:3526437
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wnt9btm1.1Amc/Wnt9btm1.1Amc involves: 129/Sv * 129X1/SvJ * C57BL/6J MGI:3848509
hm2
 		Wnt9btm1.1Amc/Wnt9btm1.1Amc involves: 129X1/SvJ * C57BL/6 * CBA MGI:3589874
hm3
 		Wnt9btm1.1Amc/Wnt9btm1.1Amc involves: 129X1/SvJ * C57BL/6J * NMRI MGI:3845626
ht4
 		Wnt9btm1Amc/Wnt9btm1.1Amc involves: 129X1/SvJ * C57BL/6 * CBA MGI:3589875
cn5
 		Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Tg(Hoxb7-cre)13Amc/0
Wnt9btm1.1Amc/Wnt9btm1.1Amc 		involves: 129X1/SvJ * C57BL/6 * CBA MGI:3716215
cn6
 		Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129X1/SvJ * C57BL/6 * CBA MGI:5428000
cn7
 		Ctnnb1tm1Mmt/Ctnnb1+
Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(Cdh16-cre)91Igr/0 		involves: 129X1/SvJ * ICR MGI:5428001
cn8
 		Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(Cdh16-cre)91Igr/0 		involves: 129X1/SvJ * ICR MGI:5427999
cx9
 		Six2tm1Gco/Six2tm1Gco
Wnt9btm1.1Amc/Wnt9btm1.1Amc 		involves: 129/Sv * 129X1/SvJ * C57BL/6J MGI:3848508
cx10
 		Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Wnt9btm1.1Amc/Wnt9btm1.1Amc 		involves: 129X1/SvJ * C57BL/6 * CBA MGI:3716214
cx11
 		Six2tm1Gco/Six2tm1Gco
Wnt9btm1.1Amc/Wnt9btm1.1Amc 		involves: 129X1/SvJ * C57BL/6J * NMRI MGI:3845624


Genotype
MGI:3848509
hm1
Allelic
Composition		 Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic
Background		 involves: 129/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal kidney development ( J:148455 )
• at 12.5 dpc, the amount of cap mesenchyme is reduced compared to controls
delayed kidney development ( J:148455 )
• no renal vesicle formation is observed at 12.5 dpc




Genotype
MGI:3589874
hm2
Allelic
Composition		 Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

renal/urinary system
abnormal kidney development ( J:100575 )
• at birth only vestigial kidneys are present
• mesenchymally derived tubular epithelia is absent
impaired branching involved in ureteric bud morphogenesis ( J:100575 )
• ureteric bud invasion into the mesenchyme and initial branching is normal; however, branching after the T-stage is disrupted

reproductive system
oviduct hypoplasia ( J:100575 )
• most of the oviduct is absent at birth
absent cranial vagina ( J:100575 )
• the upper vagina is absent at birth

craniofacial
cleft upper lip ( J:100575 )
• incomplete penetrance
cleft palate ( J:100575 )
• incomplete penetrance

digestive/alimentary system
cleft palate ( J:100575 )
• incomplete penetrance

embryo
abnormal Mullerian duct morphology ( J:100575 )
• posterior extension of the Mullerian duct fails to occur
absent Wolffian ducts ( J:100575 )
• at E11.5, no histologically detectable mesonephric tubules are observed

growth/size/body
cleft upper lip ( J:100575 )
• incomplete penetrance
cleft palate ( J:100575 )
• incomplete penetrance




Genotype
MGI:3845626
hm3
Allelic
Composition		 Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal kidney development ( J:148455 )
• no renal vesicle formation is observed at 12.5 dpc
• reduction of Pax2+ve cap mesenchyme is observed at 12.5 dpc




Genotype
MGI:3589875
ht4
Allelic
Composition		 Wnt9btm1Amc/Wnt9btm1.1Amc
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (22 available)
Wnt9btm1Amc mutation (0 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
small kidney ( J:100575 )
• small kidneys with few mature nephrons are seen




Genotype
MGI:3716215
cn5
Allelic
Composition		 Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Tg(Hoxb7-cre)13Amc/0
Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Wnt1/GFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:100575 )
N
• when the Wnt1:GFP fusion protein is expressed in the Wolffian duct, embryos exhibit normal mesonephric and metanephric tubule induction, as well as caudal extension of the Mullerian duct




Genotype
MGI:5428000
cn6
Allelic
Composition		 Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (22 available)
Wnt9btm1.2Amc mutation (1 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:151498 )
• all mice treated with tamoxifen from E15.5 die by P90

renal/urinary system
kidney cyst ( J:151498 )
• in mice treated with tamoxifen from E15.5 to P10
• however, mice treated with tamoxifen after P10 do not develop cysts

growth/size/body
kidney cyst ( J:151498 )
• in mice treated with tamoxifen from E15.5 to P10
• however, mice treated with tamoxifen after P10 do not develop cysts




Genotype
MGI:5428001
cn7
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (22 available)
Wnt9btm1.2Amc mutation (1 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
kidney cyst ( J:151498 )
• cystic index at P1 is increased compared to in Wnt9btm1.1Amc/Wnt9btm1.2Amc Tg(Cdh16-cre)91Igr mice

growth/size/body
kidney cyst ( J:151498 )
• cystic index at P1 is increased compared to in Wnt9btm1.1Amc/Wnt9btm1.2Amc Tg(Cdh16-cre)91Igr mice




Genotype
MGI:5427999
cn8
Allelic
Composition		 Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cdh16-cre)91Igr mutation (1 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (22 available)
Wnt9btm1.2Amc mutation (1 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:151498 )
• most mice die between P30 and P45 with no mice surviving past P60

renal/urinary system
kidney cyst ( J:151498 )
• delayed compared to in Wnt9btm1Amc homozygotes
• few cysts at P1
• prevalent by P10
• by P15, mice develop cysts in all nephrons of glomerulus, proximal tubule, loop of Henle and collecting duct
abnormal kidney collecting duct epithelium morphology ( J:151498 )
• collecting duct epithelial cells exhibit randomized elongation unlike in wild-type mice
abnormal renal tubule epithelium morphology ( J:151498 )
• at P5, epithelium cell divisions are not oriented within the plane of the epithelium unlike in control mice
• by P30, little normal epithelia remains

growth/size/body
kidney cyst ( J:151498 )
• delayed compared to in Wnt9btm1Amc homozygotes
• few cysts at P1
• prevalent by P10
• by P15, mice develop cysts in all nephrons of glomerulus, proximal tubule, loop of Henle and collecting duct
renal glomerulus cyst ( J:151498 )




Genotype
MGI:3848508
cx9
Allelic
Composition		 Six2tm1Gco/Six2tm1Gco
Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic
Background		 involves: 129/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six2tm1Gco mutation (0 available); any Six2 mutation (15 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal kidney development ( J:148455 )
• at 12.5 dpc, the amount of cap mesenchyme is greatly reduced
delayed kidney development ( J:148455 )
• no renal vesicle formation is observed at 12.5 dpc
• ingrowth of the ureteric bud is delayed compared to controls at 11.5 dpc




Genotype
MGI:3716214
cx10
Allelic
Composition		 Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Wnt1/GFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality ( J:100575 )
• phenotype is stated to be identical to that of Wnt9btm1.1Amc homozygotes; however only limited data is presented

renal/urinary system
abnormal kidney development ( J:100575 )
• no pretubular aggregates are apparent

embryo
abnormal Mullerian duct morphology ( J:100575 )
• development is arrested




Genotype
MGI:3845624
cx11
Allelic
Composition		 Six2tm1Gco/Six2tm1Gco
Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six2tm1Gco mutation (0 available); any Six2 mutation (15 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal kidney development ( J:148455 )
• no renal vesicle formation is observed at 12.5 dpc
• ingrowth of the ureteric bud is delayed compared to Six2- or Wnt9b-null animals
• significant reduction of Pax2+ve cap mesenchyme is observed at 12.5 dpc; reduction is more severe than in Wnt9b single null mice
• renal vesicle-forming progenitors are depleted in the cap mesenchyme




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory