Phenotypes associated with this allele

• Allele Symbol: Tex15^tm1Jw
• Allele Name: targeted mutation 1, Jeremy Wang
• Allele ID: MGI:3526165
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tex15^tm1Jw/Tex15^tm1Jw	involves: 129S4/SvJae * C57BL/6	MGI:3794967

Genotype
MGI:3794967

hm1

• Allelic Composition: Tex15^tm1Jw/Tex15^tm1Jw
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Meiotic arrest in Tex15^tm1Jw/Tex15^tm1Jw mice

reproductive system

reproductive system phenotype ( J:135578 )

N • female mice are fertile

decreased male germ cell number ( J:135578 )

♂ • male germ cell numbers are decreased due to increased apoptosis

decreased testis weight ( J:135578 )

♂ • testes weigh 20% less than in heterozygous mice

abnormal spermatogenesis ( J:135578 )

♂ • apoptosis rates in testes are increased compared to in wild-type mice

arrest of male meiosis ( J:135578 )

♂ • testes lack pachytene spermatocytes and postmeiotic germ cells

male infertility ( J:135578 )

♂

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:135578 )

• DNA within spermatocytes undergoes double-strand break but fails to repair as in wild-type mice

endocrine/exocrine glands

decreased testis weight ( J:135578 )

♂ • testes weigh 20% less than in heterozygous mice

cellular

decreased male germ cell number ( J:135578 )

♂ • male germ cell numbers are decreased due to increased apoptosis

arrest of male meiosis ( J:135578 )

♂ • testes lack pachytene spermatocytes and postmeiotic germ cells

abnormal double-strand DNA break repair ( J:135578 )

• DNA within spermatocytes undergoes double-strand break but fails to repair as in wild-type mice