All Phenotypes Hoxd9<tm1Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxd9^tm1Mrc
targeted mutation 1, Mario Capecchi
MGI:3525581

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxc9^tm1Mrc/Hoxc9^tm1Mrc Hoxd9^tm1Mrc/Hoxd9^tm1Mrc	involves: 129S7/SvEvBrd	MGI:4358350
cx2	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxc9^tm1Mrc/Hoxc9⁺ Hoxd9^tm1Mrc/Hoxd9^tm1Mrc	involves: 129S7/SvEvBrd	MGI:4358353
cx3	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxd9^tm1Mrc/Hoxd9^tm1Mrc	Not Specified	MGI:3526127
cx4	Hoxa9^tm1Mrc/Hoxa9⁺ Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxd9^tm1Mrc/Hoxd9^tm1Mrc	Not Specified	MGI:3526128
cx5	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9⁺ Hoxd9^tm1Mrc/Hoxd9^tm1Mrc	Not Specified	MGI:3526129

Allelic Composition	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxc9^tm1Mrc/Hoxc9^tm1Mrc Hoxd9^tm1Mrc/Hoxd9^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa9^tm1Mrc mutation (0 available); any Hoxa9 mutation (17 available)
Hoxb9^tm1Mrc mutation (0 available); any Hoxb9 mutation (12 available)
Hoxc9^tm1Mrc mutation (0 available); any Hoxc9 mutation (22 available)
Hoxd9^tm1Mrc mutation (0 available); any Hoxd9 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

decreased caudal vertebrae number ( J:124112 )

• two fewer than in wild-type mice

skeleton

decreased caudal vertebrae number ( J:124112 )

• two fewer than in wild-type mice

abnormal sternebra morphology ( J:124112 )

• mice lack distinct sternebrae unlike in wild-type mice

abnormal sternum ossification ( J:124112 )

• the sternum is ossified and mispatterened along its entire anterior posterior length

abnormal rib joint morphology ( J:124112 )

• the first rib does not always attach to the sternum unlike in wild-type mice

• rib attachment to the sternum continues past T7 to T13 and the transformed 'T14'

abnormal rib development ( J:124112 )

• posterior rib growth is abnormal with 4 vertebrae posterior to T13 forming ribs

rib fusion ( J:124112 )

• distal fusion of anterior-most ribs

small thoracic cage ( J:124112 )

abnormal sacral vertebrae morphology ( J:124112 )

• shifted posteriorly with displacement of pelvic attachment

vertebral transformation ( J:124112 )

• mice exhibit anterior homeotic transformations through the posterior thoracic skeleton and into the lumbar region

• the axial skeleton posterior to the transformations are shifted caudally by two vertebral segments

thoracic vertebral transformation ( J:124112 )

• T8 through L2 exhibit a T7-like phenotype

lumbar vertebral transformation ( J:124112 )

• T8 through L2 exhibit a T7-like phenotype

• L5 has an L3-like phenotype

Allelic Composition	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxc9^tm1Mrc/Hoxc9⁺ Hoxd9^tm1Mrc/Hoxd9^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal rib joint morphology ( J:124112 )

• mice exhibit two extra ribbed vertebrae on T8 and T9 that attach to the sternum

abnormal thoracic vertebrae morphology ( J:124112 )

• mice exhibit two extra ribbed vertebrae on T8 and T9 that attach to the sternum

Allelic Composition	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxd9^tm1Mrc/Hoxd9^tm1Mrc
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa9^tm1Mrc mutation (0 available); any Hoxa9 mutation (17 available)
Hoxb9^tm1Mrc mutation (0 available); any Hoxb9 mutation (12 available)
Hoxd9^tm1Mrc mutation (0 available); any Hoxd9 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:52279 )

• at day 12.5 of pregnancy branching of the epithelial ductal system is significantly reduced

mammary gland hypoplasia ( J:52279 )

• mammary glands in virgin females appear normal, however during and after pregnancy mammary gland hypoplasia as a result of a delay in growth and differentiation of the mammary epithelium is seen

• after parturition reduced numbers of lobuloalveolar structures and large amounts of intracellular fat droplets are seen

abnormal lactation ( J:52279 )

• mutant females have difficulty nursing pups with most pups dying shortly after birth of dehydration

integument

abnormal branching of the mammary ductal tree ( J:52279 )

• at day 12.5 of pregnancy branching of the epithelial ductal system is significantly reduced

mammary gland hypoplasia ( J:52279 )

• mammary glands in virgin females appear normal, however during and after pregnancy mammary gland hypoplasia as a result of a delay in growth and differentiation of the mammary epithelium is seen

• after parturition reduced numbers of lobuloalveolar structures and large amounts of intracellular fat droplets are seen

abnormal lactation ( J:52279 )

• mutant females have difficulty nursing pups with most pups dying shortly after birth of dehydration

Allelic Composition	Hoxa9^tm1Mrc/Hoxa9⁺ Hoxb9^tm1Mrc/Hoxb9^tm1Mrc Hoxd9^tm1Mrc/Hoxd9^tm1Mrc
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa9^tm1Mrc mutation (0 available); any Hoxa9 mutation (17 available)
Hoxb9^tm1Mrc mutation (0 available); any Hoxb9 mutation (12 available)
Hoxd9^tm1Mrc mutation (0 available); any Hoxd9 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

mammary gland hypoplasia ( J:52279 )

• mammary glands in virgin females appear normal, however during and after pregnancy mammary gland hypoplasia as a result of a delay in growth and differentiation of the mammary epithelium is seen

• after parturition reduced numbers of lobuloalveolar structures and large amounts of intracellular fat droplets are seen

abnormal lactation ( J:52279 )

• mutant females have difficulty nursing pups with most pups dying shortly after birth of dehydration

integument

mammary gland hypoplasia ( J:52279 )

• mammary glands in virgin females appear normal, however during and after pregnancy mammary gland hypoplasia as a result of a delay in growth and differentiation of the mammary epithelium is seen

• after parturition reduced numbers of lobuloalveolar structures and large amounts of intracellular fat droplets are seen

abnormal lactation ( J:52279 )

• mutant females have difficulty nursing pups with most pups dying shortly after birth of dehydration

Allelic Composition	Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Hoxb9^tm1Mrc/Hoxb9⁺ Hoxd9^tm1Mrc/Hoxd9^tm1Mrc
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa9^tm1Mrc mutation (0 available); any Hoxa9 mutation (17 available)
Hoxb9^tm1Mrc mutation (0 available); any Hoxb9 mutation (12 available)
Hoxd9^tm1Mrc mutation (0 available); any Hoxd9 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

mammary gland hypoplasia ( J:52279 )

• mammary glands in virgin females appear normal, however during and after pregnancy mammary gland hypoplasia as a result of a delay in growth and differentiation of the mammary epithelium is seen

• after parturition reduced numbers of lobuloalveolar structures and large amounts of intracellular fat droplets are seen

abnormal lactation ( J:52279 )

• mutant females have difficulty nursing pups with most pups dying shortly after birth of dehydration

integument

mammary gland hypoplasia ( J:52279 )

• mammary glands in virgin females appear normal, however during and after pregnancy mammary gland hypoplasia as a result of a delay in growth and differentiation of the mammary epithelium is seen

• after parturition reduced numbers of lobuloalveolar structures and large amounts of intracellular fat droplets are seen

abnormal lactation ( J:52279 )

• mutant females have difficulty nursing pups with most pups dying shortly after birth of dehydration

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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