All Phenotypes Adam10<tm1Psa> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam10^tm1Psa/Adam10^tm1Psa	either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	MGI:3522637
cx2	Adam10^tm1Psa/Adam10⁺ Hr^hr/Hr^hr	involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/Skh	MGI:6163722
cx3	Adam10^Pied/Adam10^tm1Psa Hr^hr/Hr^hr	involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/SkhKcl	MGI:6163720

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:94943 )

• no viable embryos obtained after E9.5

cardiovascular system

absent intersomitic vessels ( J:94943 )

• absence of smaller segmental vessel branches between somites

failure of vascular branching ( J:94943 )

• absence of smaller segmental vessel branches between somites

abnormal vitelline vasculature morphology ( J:94943 )

• enlarged extraembryonic blood vessels filled with large numbers of erythrocytes in the yolk sac at E9.5

delayed heart development ( J:94943 )

• severely retarded development of the heart, with morphology corresponding at E9.5 to an E7.5-E8 stage embryo

distended pericardium ( J:94943 )

• enlarged pericardial sacs that occasionally expanded to extreme sizes at E9.5

embryo

abnormal vitelline vasculature morphology ( J:94943 )

• enlarged extraembryonic blood vessels filled with large numbers of erythrocytes in the yolk sac at E9.5

small first pharyngeal arch ( J:94943 )

• reduced first branchial arch

decreased embryo size ( J:94943 )

• reach about 2/3 of the size of wild-type, with the body region distal to the forelimb buds most growth retarded

abnormal paraxial mesoderm morphology ( J:94943 )

• caudal most somite was followed by a protruding bulge of paraxial mesoderm, corresponding to fused somites

abnormal neural tube morphology ( J:94943 )

• fusing neural tubes had irregularly shaped lateral neuroepithelial walls

abnormal somite development ( J:94943 )

• only the rostral four or five pairs of somites appeared normal although they were irregular in size and less well delineated

• caudal most somite was followed by a protruding bulge of paraxial mesoderm, corresponding to fused somites

abnormal umbilical cord morphology ( J:94943 )

• had extracorporal mesenchymal swellings at the insertion of the umbilical cord

abnormal visceral yolk sac morphology ( J:94943 )

• yolk sacs had enlarged extraembryonic blood vessels filled with large numbers of embryonic erythrocytes and their progenitors

growth/size/body

decreased embryo size ( J:94943 )

• reach about 2/3 of the size of wild-type, with the body region distal to the forelimb buds most growth retarded

nervous system

abnormal neural tube morphology ( J:94943 )

• fusing neural tubes had irregularly shaped lateral neuroepithelial walls

abnormal forebrain development ( J:94943 )

• foreshortened forebrain anlage at E9.5

abnormal pontine flexure morphology ( J:94943 )

• had an abnormal hindbrain flexure at E9.5

craniofacial

small first pharyngeal arch ( J:94943 )

• reduced first branchial arch

Allelic Composition	Adam10^tm1Psa/Adam10⁺ Hr^hr/Hr^hr
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/Skh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10^tm1Psa mutation (0 available); any Adam10 mutation (37 available)
Hr^hr mutation (17 available); any Hr mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

hairless ( J:262499 )

abnormal skin pigmentation ( J:262499 )

• light brown, freckle-like spots or macules with a striated appearance at 5 months of age

pigmentation

abnormal skin pigmentation ( J:262499 )

• light brown, freckle-like spots or macules with a striated appearance at 5 months of age

Allelic Composition	Adam10^Pied/Adam10^tm1Psa Hr^hr/Hr^hr
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/SkhKcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10^Pied mutation (0 available); any Adam10 mutation (37 available)
Adam10^tm1Psa mutation (0 available); any Adam10 mutation (37 available)
Hr^hr mutation (17 available); any Hr mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small pharyngeal arch ( J:262499 )

• at E9.5

caudal body truncation ( J:262499 )

• at E9.5

decreased embryo size ( J:262499 )

• at E9.5

abnormal neural tube morphology ( J:262499 )

• irregularly shaped at E9.5

abnormal somite border morphology ( J:262499 )

• not delineated at E9.5

cardiovascular system

abnormal heart looping ( J:262499 )

• linear at E9.5

enlarged pericardium ( J:262499 )

• at E9.5

nervous system

abnormal neural tube morphology ( J:262499 )

• irregularly shaped at E9.5

telencephalon hypoplasia ( J:262499 )

• at E9.5

growth/size/body

decreased embryo size ( J:262499 )

• at E9.5

craniofacial

small pharyngeal arch ( J:262499 )

• at E9.5

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