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Allele Symbol Allele Name Allele ID |
Dmbt1tm1Kumc targeted mutation 1, Robert C De Lisle MGI:3514149 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice have same response severity to dextran sodium sulfate-induced colitis (DSS colitis) as wild-type
• colon morphology, weight loss and inflammatory response are similar to wild-type in DSS-induced colitis model
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice have same response severity to caerulein-induced acute pancreatitis as wild-type; pancreatic tissue edema, inflammation, increased tissue myeloperoxidase and serum amylase levels, inflammation, and apoptosis in response to pancreatitis is the same
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| N |
• up to 1 year of age, mice do not develop tumors, with none detected in pancreas or gastrointestinal tract
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• majority of mice (86%) die early (before 9 months of age), or are euthanized due to occurrence of obvious tumor mass
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| N |
• mice do not develop tumors in pancreas or gastrointestinal tract regardless of Trp53 status
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some mice die before 9 month experimental end-point of 9 months due to development of obvious tumor mass
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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