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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pcp2-cre)756Mro
transgene insertion 756, Silvia Marino
MGI:3513599
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rb1tm2Brn/Rb1tm2Brn
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pcp2-cre)756Mro/0 		involves: 129P2/OlaHsd * FVB MGI:3707500
cn2
 		Rb1tm2Brn/Rb1tm2Brn
Tg(Pcp2-cre)756Mro/0 		involves: 129P2/OlaHsd * FVB MGI:3707501
cn3
 		Ptentm1Mro/Ptentm1Mro
Tg(Pcp2-cre)756Mro/0 		involves: FVB/N MGI:3805877


Genotype
MGI:3707500
cn1
Allelic
Composition		 Rb1tm2Brn/Rb1tm2Brn
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pcp2-cre)756Mro/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (3 available); any Rb1 mutation (107 available)
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (60 available)
Tg(Pcp2-cre)756Mro mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal Purkinje cell morphology ( J:83783 )
• some Purkinje cells show enlarged nuclei with abnormal hourglass or kidney shapes




Genotype
MGI:3707501
cn2
Allelic
Composition		 Rb1tm2Brn/Rb1tm2Brn
Tg(Pcp2-cre)756Mro/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (3 available); any Rb1 mutation (107 available)
Tg(Pcp2-cre)756Mro mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellum vermis morphology ( J:83783 )
• at P15, the vermis is considerably reduced in size, but less than when both Rbl1 alleles are lost




Genotype
MGI:3805877
cn3
Allelic
Composition		 Ptentm1Mro/Ptentm1Mro
Tg(Pcp2-cre)756Mro/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Mro mutation (1 available); any Pten mutation (81 available)
Tg(Pcp2-cre)756Mro mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellar Purkinje cell layer ( J:77123 )
• mice exhibit subtle irregularities in the Purkinje cell lining compared to in wild-type mice
abnormal Purkinje cell morphology ( J:77123 )
• increased in size compared to in wild-type mice
Purkinje cell degeneration ( J:77123 )
• at 17 and 20 weeks
abnormal Purkinje cell dendrite morphology ( J:77123 )
• dendrites and descending axons are thickened compared to in wild-type mice




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory