Phenotypes associated with this allele

• Allele Symbol: Tg(Pcp2-cre)756Mro
• Allele Name: transgene insertion 756, Silvia Marino
• Allele ID: MGI:3513599
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rb1^tm2Brn/Rb1^tm2Brn Rbl1^tm1Htr/Rbl1^tm1Htr Tg(Pcp2-cre)756Mro/0	involves: 129P2/OlaHsd * FVB	MGI:3707500
cn2	Rb1^tm2Brn/Rb1^tm2Brn Tg(Pcp2-cre)756Mro/0	involves: 129P2/OlaHsd * FVB	MGI:3707501
cn3	Pten^tm1Mro/Pten^tm1Mro Tg(Pcp2-cre)756Mro/0	involves: FVB/N	MGI:3805877

Genotype
MGI:3707500

cn1

• Allelic Composition: Rb1^tm2Brn/Rb1^tm2Brn; Rbl1^tm1Htr/Rbl1^tm1Htr; Tg(Pcp2-cre)756Mro/0
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal Purkinje cell morphology ( J:83783 )

• some Purkinje cells show enlarged nuclei with abnormal hourglass or kidney shapes

Genotype
MGI:3707501

cn2

• Allelic Composition: Rb1^tm2Brn/Rb1^tm2Brn; Tg(Pcp2-cre)756Mro/0
• Genetic Background: involves: 129P2/OlaHsd * FVB

nervous system

abnormal cerebellum vermis morphology ( J:83783 )

• at P15, the vermis is considerably reduced in size, but less than when both Rbl1 alleles are lost

Genotype
MGI:3805877

cn3

• Allelic Composition: Pten^tm1Mro/Pten^tm1Mro; Tg(Pcp2-cre)756Mro/0
• Genetic Background: involves: FVB/N

nervous system

abnormal cerebellar Purkinje cell layer ( J:77123 )

• mice exhibit subtle irregularities in the Purkinje cell lining compared to in wild-type mice

abnormal Purkinje cell morphology ( J:77123 )

• increased in size compared to in wild-type mice

Purkinje cell degeneration ( J:77123 )

• at 17 and 20 weeks

abnormal Purkinje cell dendrite morphology ( J:77123 )

• dendrites and descending axons are thickened compared to in wild-type mice