Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a3tm1Gdu mutation
(1 available);
any
Aldh1a3 mutation
(25 available)
|
|
|
mortality/aging
vision/eye
|
|
• excessive thickening of the neural retina at E14.5
|
|
|
• at E14.5 a prominent retrolenticular membrane is present
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a3tm1Gdu mutation
(1 available);
any
Aldh1a3 mutation
(25 available)
|
|
|
renal/urinary system
|
N |
• apparently normal kidney development
|
vision/eye
|
|
• failure of ventral invagination of the optic vesicle at the point that defines the junction of the ventral retina and optic stalk is seen at E10.5 and E11.5 following maternal dietary retinoic acid treatment ending at E8.5
|
cellular
|
|
• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice
|
vision/eye
|
|
• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice
• excessive invasion of the periocular mesenchyme into the anterior retina at E14.5
• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores periocular mesenchyme growth to nearly normal
|
|
|
• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice
|
|
|
• thickened folds at E14.5
|
|
|
• excessive thickening of the neural retina at E14.5
• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores neural retina thickness to nearly normal
|
|
|
• absent at E14.5
• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores vitreous body development
|
|
|
• at E14.5, a prominent retrolenticular membrane is present
|
embryo
|
|
• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice
• excessive invasion of the periocular mesenchyme into the anterior retina at E14.5
• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores periocular mesenchyme growth to nearly normal
|
|
|
• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice
|
growth/size/body
|
|
• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice
• excessive invasion of the periocular mesenchyme into the anterior retina at E14.5
• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores periocular mesenchyme growth to nearly normal
|
|
|
• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice
|
vision/eye
|
|
• at E10.5 the ventral optic vesicle has not invaginated to form a complete optic cup following maternal dietary retinoic acid treatment ending at E8.5
• however, dorsal invagination does occur
|
renal/urinary system
|
|
• greatly reduced in size compared with homozygous Aldh1a2tm1Gdu mice at E14
|
|
|
• contain few ureteric bud branches or developing nephrons at E14
|
hearing/vestibular/ear
|
|
• semicircular abnormalities at E14.5 similar to mice heterozygous for the Chd7 mutation alone
|
hearing/vestibular/ear
|
|
• reduced penetrance of semicircular canal abnormalities compared to mice heterozygous for the Chd7 mutation alone
|
Analysis Tools