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Allele Symbol Allele Name Allele ID |
Ts(1716)65Dn trisomy, Chr 16 translocation to Chr 17, Davisson 65 MGI:3512067 |
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| Summary |
13 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• transplanted Lewis lung and B16F10 tumor cells exhibit growth suppression with reduced microvessel density compared to tumor cells transplanted into wild-type mice but not as much as in Ts(1716)65Dn mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice perform similar to control mice in a Morris water maze with a visible or hidden platform
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• mice have craniofacial dysmorpholgy that is similar to that seen in Ts(1716)65Dn mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice are produced in the expected Mendelian ratio
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• electrocardiogram phenotypes observed in Ts(1716)65Dn mice are partially rescued
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• transplanted Lewis lung and B16F10 tumor cells exhibit growth suppression with reduced microvessel density compared to tumor cells transplanted into wild-type mice
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• in 22 degree water there is increased latency of acquisition of the hidden platform in the Morris water maze test
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• physical exercise improves performance of 12-13 month old mutants, but not controls, in the acquisition of the Morris water maze
(J:170195)
• however, physical exercise has no effect on anxiety or depression behaviors in mutants
(J:170195)
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• output of a grip strength meter shows reduced grip force relative to controls
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• although activity during the light cycle is not different from that of controls, during the dark cycle the total activity is significantly greater than in background controls
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• significantly increased dark cycle rearing
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• significantly increased dark cycle horizontal and vertical stereotypic activity
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• the length from the nost to the tip of the tail and the length from the nose to the base of the tail are shorter than in background controls
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• mutants exhibit reduced cell proliferation and apoptosis in the hippocampus
• mutants exhibit a smaller subgranular zone
• exercise has no effect on the size of subgranular zone
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• mutants exhibit a smaller dentate gyrus volume
• exercise has no effect on the size of dentate gyrus volume
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• mutants exhibit reduced number of granule cells
• exercise has no effect on the number of granule cells
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• hippocampal neurogenesis is reduced
• exercise has no effect on hippocampal neurogenesis
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Down syndrome | DOID:14250 |
OMIM:190685 |
J:170195 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the length from the nost to the tip of the tail is shorter than in background controls, although the length from the nose to the base of the tail does not have a statistically significant difference
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• in 22 degree water there is increased latency of acquisition of the hidden platform in the Morris water maze test
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• output of a grip strength meter shows reduced grip force relative to controls
|
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• although activity during the light cycle is not different from that of controls, during the dark cycle the total activity is significantly greater than in background controls
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• significantly increased dark cycle rearing
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• significantly increased dark cycle horizontal and vertical stereotypic activity
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Down syndrome | DOID:14250 |
OMIM:190685 |
J:153579 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only 3 fertile males out of 39 tested
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• lower level of responses in a fear conditioning test compared with wild-type mice
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• in the learning and reversal phase, mice take longer mice to reach the platform in a Morris water maze than wild-type
• more severe than in Ts(1716)66Yah mice
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• lower percentage of spontaneous alterations in a Y-maze test
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• reduced travel in the center of an open field
• in a Morris water maze
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• mice spend more time exploring a novel object compared with wild-type mice
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• mice travel greater distance in an open field and in the light and dark phases
• increased number of Y-maze arm entries
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• even in the habituation phase
• however, rearing the center of an open field is decreased
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• impaired nest building behavior
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• with more pronounced deformations than in Ts(1716)66Yah mice
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• more severe than in Ts(1716)66Yah mice
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• with more pronounced deformations than in Ts(1716)66Yah mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Down syndrome | DOID:14250 |
OMIM:190685 |
J:331897 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a more generalized shortening of the skull along the anterior posterior axis compared to in Ts(1216)1Cje mice
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• mice exhibit a reduction in the height of the incisive alveolar segment compared to in wild-type mice
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• reduced in size compared to in wild-type mice
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• reduced in size compared to in wild-type mice
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• mice exhibit a more generalized shortening of the skull along the anterior posterior axis compared to in Ts(1216)1Cje mice
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• mice exhibit a reduction in the height of the incisive alveolar segment compared to in wild-type mice
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• reduced in size compared to in wild-type mice
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• reduced in size compared to in wild-type mice
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• mice exhibit a reduction in the height of the incisive alveolar segment compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Cardiovascular abnormalities in Ts(1716)65Dn/0 mice
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• aberrant right subclavian artery arising from the distal part of the aortic arch
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• great vessel and cardiac malformation in 1 of 18 mice that died postnatally
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• 1 in 18 newborns exhibit an upper communication of the ventricles, indication a septation defect of the ventricles
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• flecainide-treated mice exhibit a specific electrophysiologic signature as compare to wild-type mice
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• in the frontal plane
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• fragmented time-course with decreased S wave amplitude
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• larger QT and QTc
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Purkinje cell density is reduced to 90% of that in control mice
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• granule cell density is reduced to 76% of that in control mice
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• cerebellar volume is reduced to 88% of that in control mice
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• mice show impairment in a Morris water maze test
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• malignant lymphoma in the spleen and lymph nodes is observed in some mutants
• megakaryocytes are numerous is some spleens, suggesting a relation to megakaryocytic leukemia
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• splenic architecture is replaced by proliferated immature mononuclear cells arranged in follicular aggregates indicating follicular lymphoma
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• some mutants exhibit malignant tumors of liver, colon, or lung
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• splenic red pulp is largely obliterated
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• splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles
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• irregular
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• splenic red pulp is largely obliterated
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• splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles
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• irregular
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Down syndrome | DOID:14250 |
OMIM:190685 |
J:174270 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Purkinje cell linear density is decreased compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• significantly more sperm with head abnormalities
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• significantly reduced frequencies of sperm with progressive motility
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• Leydig cells are clustered loosely in expanded interstitial compartment
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• only a few Sertoli cells are visible; germ cells appear to be detached from the remaining Sertoli cells
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• testes are 37.9% of control testes weights
(J:96650)
• significantly smaller testes than controls
(J:117029)
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• spermatocytes beyond pachytene stage and round spermatids are significantly reduced in number, while elongated spermatids are rare and remaining spermatids have deformed nuclei
(J:96650)
(J:117029)
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• sperm concentration was significantly reduced below controls
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• many tubules contain germ cells in arrested at meiotic metaphase 1
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• presence of an intact extra chromosome interferes with chromosome pairing in meiosis
• produced no progeny
• fail to produce a vaginal plug
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• significantly more sperm with head abnormalities
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• sperm concentration was significantly reduced below controls
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• significantly reduced frequencies of sperm with progressive motility
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• mice are ~20% smaller in size compared to normal littermates postnatally
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• dendritic spine density on granule cells is decreased on average by 17% compared to in wild-type mice
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• the area of presynaptic elements (p38+) is increased in the fascia dentate and motor cortex
• in young and old mice alike, small presynaptic boutons are decreased and large presynaptic boutons are increased in the fascia dentate and motor cortex with the average diameter of a presynaptic bouton increased by 40% in the cortex
• 18% of dendritic spines are enlarged and display irregular heads or a globular shape
• average synapse length is increased 34% in the hippocampus and 25% in the cortex
• glutamatergic synapses are distributed 33% on the dendritic shaft (compared to 51% in wild-type mice) and 67% (compared to 49% in wild-type mice) on the heads or necks of the dendritic spines
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• in fascia dentate, spine density is significantly decreased on dendrites of granule cells; dendritic spines are significantly enlarged; dendritic width is similar to controls
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• dendritic spine density on granule cells is decreased on average by 17% compared to in wild-type mice
• 18% of spines are enlarged and display irregular heads or a globular shape
• basal dentritic spine density in CA1 is increased
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• Leydig cells are clustered loosely in expanded interstitial compartment
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• only a few Sertoli cells are visible; germ cells appear to be detached from the remaining Sertoli cells
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• testes are 37.9% of control testes weights
(J:96650)
• significantly smaller testes than controls
(J:117029)
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Down syndrome | DOID:14250 |
OMIM:190685 |
J:94569 , J:96650 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• size difference was most pronounced along the rostralcaudal axis
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• cranial vault is enlarged
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• mice show a Down's Syndrome-like pattern of mandible reduction
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• size difference was most pronounced along the rostralcaudal axis
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• cranial vault is enlarged
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• mice show a Down's Syndrome-like pattern of mandible reduction
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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