Ts(17¹⁶)65Dn
Radiation induced Allele Detail

Summary

• Symbol: Ts(17¹⁶)65Dn
• Name: trisomy, Chr 16 translocation to Chr 17, Davisson 65
• MGI ID: MGI:3512067
• Synonyms: T(16C3-4;17A2)65Dn, Ts16, Ts65Dn
• Gene: Ts(17¹⁶)65Dn Location: unknown Genetic Position: Chr16, Syntenic

Cardiovascular abnormalities in Ts(17¹⁶)65Dn/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: DBA/2J

Mutation description

• Allele Type: Radiation induced
• Mutation: Translocation
• Ts(17¹⁶)65Dn involves 140 genes/genome features (Ncam2, 7120432I05Rik, Gm49558 ...) View all
• Mutation details: About 15% of the distal end of chromosome 16 (about 13.4 Mb; between Ncam2 (81,624,530 bp; NCBI37/mm9) and Mrpl39 (84,718,526; NCBI37/mm9)) is fused to less than 10% of the centromeric end of chromosome 17 (about 5 to 10 Mb; between RP23-147G23, Synj2 (5,988,977 bp; NCBI37/mm9) and D17Mit58 (10,489,635 bp; NCBI37/mm9)) to form a small translocation chromosome. The translocation breaks mouse Chr 16 just proximal to the amyloid precursor protein ( App ) gene and contains the HSA21-homologous genes from App to the telomere. The translocation chromosome also contains the centromere and a small portion (~5%) of Chr 17. Northern and Western blotting and enzyme activity assays demonstrate that genes on the translocation product are expressed at elevated levels in segmentally trisomic animals. (J:30229, J:71031, J:178871)

Disease models

Expression

In Mice Carrying this Mutation:	28 assay results
In Structures Affected by this Mutation:	17 anatomical structures

Tumor Data

List all tumor models in MMHCdb carrying Ts(17¹⁶)65Dn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ts(17 16 )65Dn Mutation: 2 strains or lines available

References

• Original: J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
• All: 310 reference(s)