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Radiation induced Allele Detail
Symbol: Ts(1716)65Dn
Name: trisomy, Chr 16 translocation to Chr 17, Davisson 65
MGI ID: MGI:3512067
Synonyms: T(16C3-4;17A2)65Dn, Ts16, Ts65Dn
Gene: Ts(1716)65Dn  Location: unknown  Genetic Position: Chr16, Syntenic
Cardiovascular abnormalities in Ts(1716)65Dn/0 mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  DBA/2J
Allele Type:    Radiation induced
Mutation:    Translocation
  Ts(1716)65Dn involves 140 genes/genome features (Ncam2, 7120432I05Rik, Gm49558 ...) View all
Mutation detailsAbout 15% of the distal end of chromosome 16 (about 13.4 Mb; between Ncam2 (81,624,530 bp; NCBI37/mm9) and Mrpl39 (84,718,526; NCBI37/mm9)) is fused to less than 10% of the centromeric end of chromosome 17 (about 5 to 10 Mb; between RP23-147G23, Synj2 (5,988,977 bp; NCBI37/mm9) and D17Mit58 (10,489,635 bp; NCBI37/mm9)) to form a small translocation chromosome. The translocation breaks mouse Chr 16 just proximal to the amyloid precursor protein ( App ) gene and contains the HSA21-homologous genes from App to the telomere. The translocation chromosome also contains the centromere and a small portion (~5%) of Chr 17. Northern and Western blotting and enzyme activity assays demonstrate that genes on the translocation product are expressed at elevated levels in segmentally trisomic animals. (J:30229, J:71031, J:178871)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 28 assay results
In Structures Affected by this Mutation: 17 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Ts(1716)65Dn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ts(1716)65Dn Mutation:  2 strains or lines available
Original:  J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
All:  310 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory