About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Suz12+
wild type
MGI:3510867
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Suz12Plt8/Suz12+ involves: 129 * C57BL/6 MGI:6116287
ht2
 		Suz12Gt(Betageo)1Khe/Suz12+ involves: 129P2/OlaHsd MGI:5699869
ht3
 		Suz12tm1Xmir/Suz12+ Not Specified MGI:3850321
ht4
 		Suz12tm1Hko/Suz12+ Not Specified MGI:4946504
cx5
 		Mpltm1Wsa/Mpltm1Wsa
Suz12Plt8/Suz12+ 		B6.Cg-Mpltm1Wsa Suz12Plt8 MGI:3796621
cx6
 		Mpltm1Wsa/Mpltm1Wsa
Suz12Gt(Betageo)1Khe/Suz12+ 		involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:3796626
cx7
 		Nf1tm1Tyj/Nf1+
Suz12Gt(Betageo)1Khe/Suz12+
Trp53tm1Tyj/Trp53+ 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:5699874
cx8
 		Nf1tm1Tyj/Nf1+
Suz12Gt(Betageo)1Khe/Suz12+ 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:5699877
cx9
 		Mtf2tm1.1Hko/Mtf2tm1.1Hko
Suz12tm1Hko/Suz12+ 		involves: C57BL/6 MGI:4946505


Genotype
MGI:6116287
ht1
Allelic
Composition		 Suz12Plt8/Suz12+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12Plt8 mutation (0 available); any Suz12 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytosis ( J:136262 )
• although not statistically significant platelet count was mildly elevated
increased leukocyte cell number ( J:136262 )
• due to an increased number of lymphocytes
• platelet volume, red cell count, and hematocrit were not affected

immune system
increased leukocyte cell number ( J:136262 )
• due to an increased number of lymphocytes
• platelet volume, red cell count, and hematocrit were not affected




Genotype
MGI:5699869
ht2
Allelic
Composition		 Suz12Gt(Betageo)1Khe/Suz12+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12Gt(Betageo)1Khe mutation (1 available); any Suz12 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased histiocytic sarcoma incidence ( J:217077 )
• 20% of mice develop histiocytic sarcoma




Genotype
MGI:3850321
ht3
Allelic
Composition		 Suz12tm1Xmir/Suz12+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12tm1Xmir mutation (0 available); any Suz12 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
spina bifida ( J:150128 )
• in some mice
diastematomyelia ( J:150128 )
• some mice exhibit diastematomyelia, splitting of the spinal cord, due to bony septa in lumbar L3 and L4 vertebrae unlike in wild-type mice
abnormal brain morphology ( J:150128 )
• 60% of mice exhibit abnormal brain morphology
• brain gray matter is lost in a gradient in some mice unlike in wild-type mice
hydrocephaly ( J:150128 )
• some mice develop secondary hydrocephalus unlike in wild-type mice
decreased corpus callosum size ( J:150128 )
• partial agenesis in some mice
enlarged tectum ( J:150128 )
• in most mice due to increased cellular proliferation
abnormal hippocampus morphology ( J:150128 )
• some mice exhibit deformations in the hippocampal cortex unlike in wild-type mice
abnormal cerebral cortex morphology ( J:150128 )
• in most mice, the posterior cortex is smaller than in wild-type mice due to reduced cellular proliferation
abnormal stratification in cerebral cortex ( J:150128 )
• disorganized in some mice
abnormal cerebellum morphology ( J:150128 )
• in pronounced cases, dramatic cerebellar herniation through the foramen magnum is observed with secondary hydrocephalus unlike in wild-type mice
• MRI imaging shows herniation of the cerebellar paraflocculus into the foramen magnum with crowded posterior fosssa in some mice unlike in wild-type mice

behavior/neurological
abnormal posture ( J:150128 )
• in severe cases, mice exhibit proturbated backs unlike wild-type mice
hindlimb paralysis ( J:150128 )
• in severe cases

embryo
spina bifida ( J:150128 )
• in some mice
diastematomyelia ( J:150128 )
• some mice exhibit diastematomyelia, splitting of the spinal cord, due to bony septa in lumbar L3 and L4 vertebrae unlike in wild-type mice

skeleton
diastematomyelia ( J:150128 )
• some mice exhibit diastematomyelia, splitting of the spinal cord, due to bony septa in lumbar L3 and L4 vertebrae unlike in wild-type mice




Genotype
MGI:4946504
ht4
Allelic
Composition		 Suz12tm1Hko/Suz12+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12tm1Hko mutation (0 available); any Suz12 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
vertebral transformation ( J:170279 )
• mice exhibit homeotic transformation of the axis compared with wild-type mice
thoracic vertebral transformation ( J:170279 )
• 57% of mice exhibit T13 to L1 transformation
cervical vertebral transformation ( J:170279 )
• 7% of mice exhibit C5 to C6 transformation
• 18% of mice exhibit C6 to T1 transformation
lumbar vertebral transformation ( J:170279 )
• 76% of mice exhibit L6 to S1 transformation




Genotype
MGI:3796621
cx5
Allelic
Composition		 Mpltm1Wsa/Mpltm1Wsa
Suz12Plt8/Suz12+
Genetic
Background		 B6.Cg-Mpltm1Wsa Suz12Plt8
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpltm1Wsa mutation (1 available); any Mpl mutation (48 available)
Suz12Plt8 mutation (0 available); any Suz12 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal thrombopoiesis ( J:136262 )
• amelioration of thrombocytopenia compared to Mpltm1Wsa , increased platelet cell number was significant but not to the wild-type level
abnormal bone marrow cell morphology/development ( J:136262 )
• hematopoietic stem cell number were increased in the bone marrow compared to Mpltm1Wsa control, but not to the wild-type level
abnormal megakaryocyte differentiation ( J:136262 )
• megakaryocyte numbers were increased in the bone marrow compared to Mpltm1Wsa control, but not to the wild-type level
thrombocytopenia ( J:136262 )
• thrombocytopenia of Mpltm1Wsa ameliorated, however platelet count is significantly lower than normal wild-type level

immune system
abnormal thrombopoiesis ( J:136262 )
• amelioration of thrombocytopenia compared to Mpltm1Wsa , increased platelet cell number was significant but not to the wild-type level

cellular
abnormal megakaryocyte differentiation ( J:136262 )
• megakaryocyte numbers were increased in the bone marrow compared to Mpltm1Wsa control, but not to the wild-type level




Genotype
MGI:3796626
cx6
Allelic
Composition		 Mpltm1Wsa/Mpltm1Wsa
Suz12Gt(Betageo)1Khe/Suz12+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpltm1Wsa mutation (1 available); any Mpl mutation (48 available)
Suz12Gt(Betageo)1Khe mutation (1 available); any Suz12 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal thrombopoiesis ( J:136262 )
• amelioration of thrombocytopenia compared to Mpltm1Wsa , increased platelet cell number was significant but not to the wild-type level
thrombocytopenia ( J:136262 )
• thrombocytopenia of Mpltm1Wsa ameliorated, however platelet count is significantly lower than normal wild-type level

immune system
abnormal thrombopoiesis ( J:136262 )
• amelioration of thrombocytopenia compared to Mpltm1Wsa , increased platelet cell number was significant but not to the wild-type level




Genotype
MGI:5699874
cx7
Allelic
Composition		 Nf1tm1Tyj/Nf1+
Suz12Gt(Betageo)1Khe/Suz12+
Trp53tm1Tyj/Trp53+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Tyj mutation (3 available); any Nf1 mutation (161 available)
Suz12Gt(Betageo)1Khe mutation (1 available); any Suz12 mutation (61 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:217077 )
• mice die by 150 days

neoplasm
increased lymphoma incidence ( J:217077 )
• 12% of mice develop lymphomas
increased histiocytic sarcoma incidence ( J:217077 )
• 62% of mice develop histiocytic sarcomas
increased neurofibrosarcoma incidence ( J:217077 )
• 38% of mice develop malignant peripheral nerve sheath tumors
• tumors develop on average at 2.3 months of age
increased hemangiosarcoma incidence ( J:217077 )
• 4% of develop angiosarcomas
increased glioma incidence ( J:217077 )
• 54% of mice develop high-grade gliomas
• gliomas develop on average at 3 months of age

nervous system
increased neurofibrosarcoma incidence ( J:217077 )
• 38% of mice develop malignant peripheral nerve sheath tumors
• tumors develop on average at 2.3 months of age
increased glioma incidence ( J:217077 )
• 54% of mice develop high-grade gliomas
• gliomas develop on average at 3 months of age




Genotype
MGI:5699877
cx8
Allelic
Composition		 Nf1tm1Tyj/Nf1+
Suz12Gt(Betageo)1Khe/Suz12+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Tyj mutation (3 available); any Nf1 mutation (161 available)
Suz12Gt(Betageo)1Khe mutation (1 available); any Suz12 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal melanocyte morphology ( J:217077 )
• 9% of mice develop melanocytic nevi

mortality/aging
premature death ( J:217077 )
• 80% of mice die by 400 days

neoplasm
increased tumor incidence ( J:217077 )
• 9% of mice develop melanocytic nevi
increased intestinal adenoma incidence ( J:217077 )
• 10% of mice develop intestinal adenomas
increased hepatocellular carcinoma incidence ( J:217077 )
• 3% of mice develop hepatocellular carcinoma
increased neurofibroma incidence ( J:217077 )
• 3% of mice develop neurofibromas
increased lymphoma incidence ( J:217077 )
• 23% of mice develop lymphoma
increased histiocytic sarcoma incidence ( J:217077 )
• 32% of mice develop histiocytic sarcoma
increased Schwannoma incidence ( J:217077 )
• 3% of mice develop schwannomas

nervous system
increased neurofibroma incidence ( J:217077 )
• 3% of mice develop neurofibromas
increased Schwannoma incidence ( J:217077 )
• 3% of mice develop schwannomas

digestive/alimentary system
increased intestinal adenoma incidence ( J:217077 )
• 10% of mice develop intestinal adenomas

liver/biliary system
increased hepatocellular carcinoma incidence ( J:217077 )
• 3% of mice develop hepatocellular carcinoma




Genotype
MGI:4946505
cx9
Allelic
Composition		 Mtf2tm1.1Hko/Mtf2tm1.1Hko
Suz12tm1Hko/Suz12+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtf2tm1.1Hko mutation (0 available); any Mtf2 mutation (314 available)
Suz12tm1Hko mutation (0 available); any Suz12 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal sternum morphology ( J:170279 )
• shifted anteriorly
increased rib number ( J:170279 )
• perfect ribs are associated with C7
vertebral transformation ( J:170279 )
• homeotic transformation is enhanced compared to in Mtf2tm1.1Hko homozygotes
thoracic vertebral transformation ( J:170279 )
• unlike in wild-type mice, a prominent spinous process is associated with T1 instead of T2
• 75% of mice exhibit T1 to T2 transformation
• 75% of mice exhibit T13 to L1 transformation
cervical vertebral transformation ( J:170279 )
• unlike in wild-type mice, anterior tuberculums are associated with C5 instead of C6 and perfect ribs are associated with C7
• 25% of mice exhibit C1 to C2 transforamtion
• 42% of mice exhibit C2 to C3 transformation
• 42% of mice exhibit C5 to C6 transformation
• 58% of mice exhibit C6 to T1 transformation
lumbar vertebral transformation ( J:170279 )
• 92% of mice exhibit L6 to S1 transformation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory