All Phenotypes Maoa<K284stop> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Maoa^K284stop Maob^tm1Shih/Y	either: (involves: 129S/SvEv * 129S6/SvEvTac) or (involves: 129S4/SvJae * 129S6/SvEvTac)	MGI:3511894
ot2	Maoa^K284stop/Y	129S6/SvEvTac-Maoa^K284stop	MGI:3798179

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased exploration in new environment ( J:93356 )

• exploratory activity is reduced as is time spent in the center of the field

increased aggression towards mice ( J:93356 )

• in the resident-intruder test mutants display a significant increase in anti-social behavior with a decrease in latency to attack and increased time spent chasing the intruder, as well as a decrease in investigative behavior

increased anxiety-related response ( J:93356 )

• in an elevated Plus-maze, mutants exhibit more freezing or crouching postures, fewer entries into either the open or closed arms, proportionally more entries into the closed arms, and fewer rearing events

homeostasis/metabolism

increased dopamine level ( J:93356 )

• dopamine levels are increased 1.7-fold

increased noradrenaline level ( J:93356 )

• brain levels of norepinephrine and phenylethylamine are increased 2.2-, and 15.7-fold, respectively

increased serotonin level ( J:93356 )

• brain levels of serotonin are increased 8.5-fold

Allelic Composition	Maoa^K284stop/Y
Genetic Background	129S6/SvEvTac-Maoa^K284stop

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maoa^K284stop mutation (2 available); any Maoa mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased aggression towards male mice ( J:136818 )

• a reduced latency to first attack to intruder male mice

• increased fighting bouts and resident mouse tail rattles in the resident intruder test

decreased locomotor activity ( J:136818 )

• decreased locomotor activity in a novel, inescapable open field

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Brunner Syndrome		DOID:0060693	OMIM:300615	J:136818

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