Phenotypes associated with this allele

• Allele Symbol: Tg(AlbLCAT)1Jdm
• Allele Name: transgene insertion 1, John D McNeish
• Allele ID: MGI:3056401
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(AlbLCAT)1Jdm/0 Tg(APOA1)1Rub/0	involves: C57BL/6 * FVB/N	MGI:3835376
cx2	Tg(AlbLCAT)1Jdm/0 Tg(APOA2)3Rub/0	involves: C57BL/6 * FVB/N	MGI:3835378
cx3	Tg(AlbLCAT)1Jdm/0 Tg(APOA1)1Rub/0 Tg(APOA2)3Rub/0	involves: C57BL/6 * FVB/N	MGI:3835379
tg4	Tg(AlbLCAT)1Jdm/0	involves: FVB/N	MGI:3835374

Genotype
MGI:3835376

cx1

• Allelic Composition: Tg(AlbLCAT)1Jdm/0; Tg(APOA1)1Rub/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:128254 )

N • despite being fed an atherogenic diet, mice exhibit no change in total cholesterol, triglyceride and HDL-cholesterol levels compared to similarly treated wild-type mice

increased circulating cholesterol level ( J:121992 )

• up to 4.2-fold compared to in Tg(APOA1)1Rub mice

increased circulating HDL cholesterol level ( J:121992 )

• 2-fold compared to in Tg(AlbLCAT)1Jdm or Tg(APOA1)1Rub mice

increased circulating LDL cholesterol level ( J:121992 )

increased circulating VLDL cholesterol level ( J:121992 )

cardiovascular system

increased susceptibility to atherosclerosis ( J:128254 )

• atherosclerotic lesions are 3-fold larger than in Tg(APOA1)1Rub mice

Genotype
MGI:3835378

cx2

• Allelic Composition: Tg(AlbLCAT)1Jdm/0; Tg(APOA2)3Rub/0
• Genetic Background: involves: C57BL/6 * FVB/N

homeostasis/metabolism

decreased circulating cholesterol level ( J:121992 )

decreased circulating HDL cholesterol level ( J:121992 )

Genotype
MGI:3835379

cx3

• Allelic Composition: Tg(AlbLCAT)1Jdm/0; Tg(APOA1)1Rub/0; Tg(APOA2)3Rub/0
• Genetic Background: involves: C57BL/6 * FVB/N

homeostasis/metabolism

increased circulating cholesterol level ( J:121992 )

• 2-fold compared to in Tg(APOA1)1Rub Tg(APOA2)3Rub mice

increased circulating HDL cholesterol level ( J:121992 )

• 2-fold compared to in Tg(AlbLCAT)1Jdm or Tg(APOA1)1Rub Tg(APOA2)3Rub mice

Genotype
MGI:3835374

tg4

• Allelic Composition: Tg(AlbLCAT)1Jdm/0
• Genetic Background: involves: FVB/N

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:128254 )

N • despite being fed an atherogenic diet, mice exhibit no change in total cholesterol, triglyceride and HDL-cholesterol levels compared to similarly treated wild-type mice

increased circulating cholesterol level ( J:121992 )

• 20% to 60% increase compared to in wild-type mice

increased circulating HDL cholesterol level ( J:121992 )

• 1.4- to 1.9-fold increase compared to in wild-type mice

decreased circulating triglyceride level ( J:121992 )

cardiovascular system

increased susceptibility to atherosclerosis ( J:128254 )

• atherosclerotic lesions are 4-fold larger than in Tg(APOA1)1Rub mice