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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Tal1-cre/ERT)1Jrg
transgene insertion 1, Joachim R Gothert
MGI:3055721
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Jam3tm1.1Chav/Jam3tm1.1Chav
Tg(Tal1-cre/ERT)1Jrg/?
involves: 129 * C57BL/6 MGI:5140202
cn2
Acvrl1tm2.1Spo/Acvrl1tm2.1Spo
Tg(Tal1-cre/ERT)1Jrg/0
involves: 129 * C57BL/6 MGI:5775199
cn3
Engtm2.1Hma/Engtm2.1Hma
Tg(Tal1-cre/ERT)1Jrg/0
involves: 129P2/OlaHsd * C57BL/6 MGI:5775190
cn4
Tg(Tal1-cre/ERT)1Jrg/0
Tsc1tm1Djk/Tsc1tm1Djk
involves: 129S4/SvJae * C57BL/6 MGI:5818157


Genotype
MGI:5140202
cn1
Allelic
Composition
Jam3tm1.1Chav/Jam3tm1.1Chav
Tg(Tal1-cre/ERT)1Jrg/?
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jam3tm1.1Chav mutation (0 available); any Jam3 mutation (16 available)
Tg(Tal1-cre/ERT)1Jrg mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• B16 cell transmigration is considerably reduced after treatment with 4-hydroxytamoxifen
• significantly reduced B16 melanoma lung metastasis after treatment with 4-hydroxytamoxifen




Genotype
MGI:5775199
cn2
Allelic
Composition
Acvrl1tm2.1Spo/Acvrl1tm2.1Spo
Tg(Tal1-cre/ERT)1Jrg/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvrl1tm2.1Spo mutation (0 available); any Acvrl1 mutation (15 available)
Tg(Tal1-cre/ERT)1Jrg mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• tamoxifen-treated mice show multiple arteriovenous (AV) shunts in the ear and skin wound areas
• tamoxifen-treated mice exhibit arteriovenous malformations in gastrointestinal tract
• tamoxifen-treated mice exhibit severe hemorrhages in the cecum
• tamoxifen-treated mice show multiple arteriovenous (AV) shunts in the ear and skin wound areas
• vessels associated with AV shunts are tortuous, enlarged, and present characteristic loops

digestive/alimentary system
• tamoxifen-treated mice exhibit arteriovenous malformations in gastrointestinal tract
• tamoxifen-treated mice exhibit severe hemorrhages in the cecum

homeostasis/metabolism
• tamoxifen-treated mice show multiple arteriovenous (AV) shunts in the ear and skin wound areas
• vessels associated with AV shunts are tortuous, enlarged, and present characteristic loops

mortality/aging
• survival rate is about 2 weeks on average after first tamoxifen injection
• lethality is most likely associated with gastrointestinal hemorrhages




Genotype
MGI:5775190
cn3
Allelic
Composition
Engtm2.1Hma/Engtm2.1Hma
Tg(Tal1-cre/ERT)1Jrg/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm2.1Hma mutation (2 available); any Eng mutation (39 available)
Tg(Tal1-cre/ERT)1Jrg mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• tamoxifen-injected adults subjected to wounding exhibit multiple arteriovenous (AV) shunts in the punched area of both the ear and the back skin
• tamoxifen-injected adults subjected to wounding exhibit tortuous and enlarged blood vessels and present multiple arteriovenous (AV) shunts in the punched area of both the ear and the back skin
• however, tamoxifen-treated mice do not exhibit signs of hemorrhages or arteriovenous malformations in internal organs and survive longer than a month

homeostasis/metabolism
• tamoxifen-injected adults subjected to wounding exhibit tortuous and enlarged blood vessels and present multiple arteriovenous (AV) shunts in the punched area of both the ear and the back skin
• however, tamoxifen-treated mice do not exhibit signs of hemorrhages or arteriovenous malformations in internal organs and survive longer than a month




Genotype
MGI:5818157
cn4
Allelic
Composition
Tg(Tal1-cre/ERT)1Jrg/0
Tsc1tm1Djk/Tsc1tm1Djk
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tal1-cre/ERT)1Jrg mutation (1 available)
Tsc1tm1Djk mutation (1 available); any Tsc1 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice administered tamoxifen from P1 to P2 show an approximate 2-fold increase in the number of mitotic cells per field in the retina
• mice administered tamoxifen from P1 to P3 exhibit increased vascular branching and endothelial cell coverage in P5 retinas

neoplasm
• at 3-4 months after tamoxifen administration, nearly 50% of mice develop liver tumors and by 6-8 months after tamoxifen, almost all mice develop liver tumors
• small metastatic nodules are seen in the lymphatic vessels near primary tumors of tamoxifen treated mice
• macrometastases are commonly present in lymph nodes and seen in distant sites such as the sternal musculature at lower frequencies
• mice administered tamoxifen at 2 months of age develop endothelial proliferative lesions from vascular malformations that lead to vascular tumors (angiosarcoma/lymphangiosarcoma); cutaneous tumors in tails and paws and liver tumors develop at 3 months or more after tamoxifen treatment
• cutaneous tumors are also seen on the lips and legs at later time points
• at 3-4 months and 6-8 months after tamoxifen administration, about 30% and 80% of mice develop cutaneous tumors, respectively
• poorly differentiated cutaneous lymphangiosarcomas are highly invasive
• mice treated with rapamycin starting 1 week after tamoxifen administration, do not develop cutaneous or liver tumors
• mice treated with rapamycin after the formation of tumors at 3 months after tamoxifen administration show halted tumor progression and even reduced tumor size and improved survival
• mice treated with axitinib after the formation of tumors at 5 months after tamoxifen show decreased proliferation of tumors, however tumors do not shrink and the number of apoptotic cells remains similar to untreated mice
• cutaneous tumors are seen on paws and legs of tamoxifen treated mice
• poorly differentiated cutaneous lymphangiosarcomas on the extremities show local invasion into bone

cardiovascular system
• mice administered tamoxifen from P1 to P3 exhibit increased vascular branching and endothelial cell coverage in P5 retinas
• mice administered tamoxifen from P1 to P3 exhibit increased vascular branching and endothelial cell coverage in P5 retinas

homeostasis/metabolism
• 1 month after tamoxifen administration, some mice develop edema, with swelling in paws and tails

liver/biliary system
• at 3-4 months after tamoxifen administration, nearly 50% of mice develop liver tumors and by 6-8 months after tamoxifen, almost all mice develop liver tumors





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory