Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm2Tajb mutation
(0 available);
any
Myf5 mutation
(17 available)
|
|
|
muscle
N |
• genotoxins suppress skeletal myogenesis as in wild-type mice
|
|
• in culture, satellite cells exhibit decreased proliferation compared to wild-type cells
|
|
• the extraocular muscle anlage is hypoplastic in some mice compared to in wild-type mice
|
|
• muscle fiber diameter is increased compared to wild-type mice
|
|
• muscles contain fibers of varying diameters
|
|
• muscles contain fibers with centrally located nuclei
|
|
• at 7 months of age mice, develop more fibrosis of the connective tissue than wild-type mice
• fibrosis of connective tissue following muscle injury is increased compared to in similarly treated wild-type mice
|
|
• muscle regeneration is delayed and accompanied by endomysial fibrosis, muscle fiber hypertrophy, increased fiber diameter heterogeneity, and fat accumulation unlike in wild-type mice
|
vision/eye
|
• the extraocular muscle anlage is hypoplastic in some mice compared to in wild-type mice
|
homeostasis/metabolism
cellular
|
• in culture, satellite cells exhibit decreased proliferation compared to wild-type cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm2Tajb mutation
(0 available);
any
Myf5 mutation
(17 available)
|
|
|
muscle
|
• muscle progenitor cells are abnormally located along the epaxial-most and hypaxial-most dermomyotome lips
|
|
• at E10 early myotome is missing
|
|
• dorsal muscles are absent
|
cellular
|
• muscle progenitor cells are abnormally located along the epaxial-most and hypaxial-most dermomyotome lips
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm2Pas mutation
(0 available);
any
Myf5 mutation
(17 available)
Myf5tm2Tajb mutation
(0 available);
any
Myf5 mutation
(17 available)
|
|
|
muscle
|
• muscle regeneration is delayed and accompanied by endomysial fibrosis, muscle fiber hypertrophy, increased fiber diameter heterogeneity, and fat accumulation unlike in wild-type mice that is not as severe as in Myf5tm2Tajb homozygotes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1tm1Gcos mutation
(0 available);
any
Abl1 mutation
(92 available)
Myf5tm2Tajb mutation
(0 available);
any
Myf5 mutation
(17 available)
Myf6tm1Tajb mutation
(0 available);
any
Myf6 mutation
(19 available)
Myod1tm2.1(icre)Glh mutation
(1 available);
any
Myod1 mutation
(23 available)
|
|
|
muscle
|
• skeletal myogenesis is not suppressed by genotoxins unlike in wild-type mice
|
homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm2Tajb mutation
(0 available);
any
Myf5 mutation
(17 available)
Tbx1tm1Pa mutation
(2 available);
any
Tbx1 mutation
(34 available)
|
|
|
muscle
|
• first-arch-derived muscles are absent in almost all mice
|
respiratory system
|
• first-arch-derived muscles are absent in almost all mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm2Tajb mutation
(0 available);
any
Myf5 mutation
(17 available)
Tbx1tm1Pa mutation
(2 available);
any
Tbx1 mutation
(34 available)
|
|
|
muscle
|
• mice exhibit sporadic asymmetric first-arch-derived muscles unlike in wild-type mice
|
respiratory system
|
• mice exhibit sporadic asymmetric first-arch-derived muscles unlike in wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm2Tajb mutation
(0 available);
any
Myf5 mutation
(17 available)
Myf6tm1Tajb mutation
(0 available);
any
Myf6 mutation
(19 available)
|
|
|
muscle
|
• mice phenocopy Myf5tm1Pas homozygotes
|
|
• mice phenocopy Myf5tm1Pas homozygotes
|
vision/eye
|
• mice phenocopy Myf5tm1Pas homozygotes
|
|
• mice phenocopy Myf5tm1Pas homozygotes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm2Tajb mutation
(0 available);
any
Myf5 mutation
(17 available)
Myf6tm1Tajb mutation
(0 available);
any
Myf6 mutation
(19 available)
|
|
|
muscle
|
• Myod expression is half that seen in wild-type mice
• before E10.5, markers of muscle differentiation are lacking
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-4Cv mutation
(3 available);
any
Dmd mutation
(153 available)
Myf5tm2Tajb mutation
(0 available);
any
Myf5 mutation
(17 available)
|
|
|
muscle
|
• the number of necrotic fibers and the size of necrotic foci is larger than in Dmdmdx-4Cv homozygotes
|
|
• muscle fiber diameter is twice as large as in wild-type mice
|
cellular
|
• the number of necrotic fibers and the size of necrotic foci is larger than in Dmdmdx-4Cv homozygotes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm2Tajb mutation
(0 available);
any
Myf5 mutation
(17 available)
Myod1tm1Jae mutation
(2 available);
any
Myod1 mutation
(23 available)
|
|
|
mortality/aging
|
• only the double homozygous mutants display postnatal lethality
|
muscle
|
• skeletal muscle differentiation is seen at E12.5 however myogenesis is still severely impaired such that mutants essentially lack skeletal muscle at birth
|
|
• mutants essentially lack skeletal muscle throughout the body including the head
|