Abl1^tm1Gcos
Targeted Allele Detail

Summary

• Symbol: Abl1^tm1Gcos
• Name: c-abl oncogene 1, non-receptor tyrosine kinase; targeted mutation 1, Giulio Cossu
• MGI ID: MGI:4939888
• Synonyms: Abl^flox
• Gene: Abl1 Location: Chr2:31578388-31694239 bp, + strand Genetic Position: Chr2, 21.86 cM, cytoband B
• Alliance: Abl1^tm1Gcos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168843
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream od exon 5. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 6. (J:168843)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abl1 Mutation: 92 strains or lines available

References

• Original: J:168843 Innocenzi A, et al., An evolutionarily acquired genotoxic response discriminates MyoD from Myf5, and differentially regulates hypaxial and epaxial myogenesis. EMBO Rep. 2011 Feb;12(2):164-71
• All: 2 reference(s)