All Phenotypes Tg(Rorc-cre)1Litt MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Rorc-cre)1Litt
transgene insertion 1, Dan R Littman
MGI:3054098

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tet1^tm1.2Jae/Tet1^tm1.2Jae Tet2^tm1.1Iaai/Tet2^tm1.1Iaai Tet3^tm1.1Yzhg/Tet3^tm1.1Yzhg Tg(Rorc-cre)1Litt/0	involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB	MGI:7439998
cn2	Tet1^tm1.2Jae/Tet1^tm1.2Jae Tet2^tm1.1Iaai/Tet2⁺ Tet3^tm1.1Yzhg/Tet3^tm1.1Yzhg Tg(Rorc-cre)1Litt/0	involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB	MGI:7439999
cn3	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0	involves: C57BL/6 * FVB	MGI:7311734
cn4	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Bptf^em1Zfa/Bptf^em1Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0	involves: C57BL/6 * FVB	MGI:7311735
cn5	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Tg(Rorc-cre)1Litt/0	involves: C57BL/6 * FVB	MGI:7311736
cn6	Bptf^em1Zfa/Bptf^em1Zfa Tg(Rorc-cre)1Litt/0	involves: C57BL/6 * FVB	MGI:7311743
cn7	Ltbr^tm1Avt/Ltbr^tm1Avt Tg(Rorc-cre)1Litt/0	Not Specified	MGI:4453324
cx8	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor^tm1(DTA)Riet Tg(Rorc-cre)1Litt/?	involves: 129P2/OlaHsd	MGI:3829422

Allelic Composition	Tet1^tm1.2Jae/Tet1^tm1.2Jae Tet2^tm1.1Iaai/Tet2^tm1.1Iaai Tet3^tm1.1Yzhg/Tet3^tm1.1Yzhg Tg(Rorc-cre)1Litt/0
Genetic Background	involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1^tm1.2Jae mutation (0 available); any Tet1 mutation (142 available)
Tet2^tm1.1Iaai mutation (2 available); any Tet2 mutation (778 available)
Tet3^tm1.1Yzhg mutation (0 available); any Tet3 mutation (59 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

enlarged spleen ( J:333574 )

• splenomegaly at age 5 weeks

hematopoietic system

enlarged spleen ( J:333574 )

• splenomegaly at age 5 weeks

immune system

enlarged spleen ( J:333574 )

• splenomegaly at age 5 weeks

enlarged lymph nodes ( J:333574 )

• lymphadenopathy at age 5 weeks

increased susceptibility to autoimmune disorder ( J:333574 )

Allelic Composition	Tet1^tm1.2Jae/Tet1^tm1.2Jae Tet2^tm1.1Iaai/Tet2⁺ Tet3^tm1.1Yzhg/Tet3^tm1.1Yzhg Tg(Rorc-cre)1Litt/0
Genetic Background	involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased effector memory T-helper cell number ( J:333574 )

• greatly reduced CD4 expression upon T cell proliferation

immune system

immune system phenotype ( J:333574 )

N	• no autoimmune phenotypes • normal spleen and lymph node size • normal proportions of naive CD44- CD62L+ T lymphocyte compartments

decreased effector memory T-helper cell number ( J:333574 )

• greatly reduced CD4 expression upon T cell proliferation

Allelic Composition	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rik^em2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Satb1^em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

immune system

increased susceptibility to bacterial infection ( J:259392 )

• in C. rodentium exposed mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• greatly reduced absolute numbers of ILC3 cells due to reduced proliferation

Allelic Composition	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Bptf^em1Zfa/Bptf^em1Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rik^em2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Bptf^em1Zfa mutation (0 available); any Bptf mutation (157 available)
Satb1^em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• reduced absolute numbers of ILC3 cells due to reduced proliferation

• however, overexpression of Zfp292 rescues ILC3 proliferation

Allelic Composition	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Tg(Rorc-cre)1Litt/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rik^em2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

immune system

abnormal interleukin secretion ( J:259392 )

• reduced IL22 secretion from intestinal lamina propria lymphocytes of C. rodentium exposed mice

increased susceptibility to bacterial infection ( J:259392 )

• C. rodentium-infected mice exhibit increased colon shortening, persistent intestinal damage, increased mortality, reduced IL22-secreting cells in the intestine, and IL22 secretion from intestinal lamina propria compared with control mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• reduced absolute numbers of ILC3 cells due to reduced proliferation

• however, ILC1 and ILC2s numbers are normal

Allelic Composition	Bptf^em1Zfa/Bptf^em1Zfa Tg(Rorc-cre)1Litt/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bptf^em1Zfa mutation (0 available); any Bptf mutation (157 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

immune system

increased susceptibility to bacterial infection ( J:259392 )

• C. rodentium-infected mice exhibit increased colon shortening, persistent intestinal damage, and increased mortality compared with control mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• reduced absolute numbers of ILC3 cells due to impaired proliferation

Allelic Composition	Ltbr^tm1Avt/Ltbr^tm1Avt Tg(Rorc-cre)1Litt/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbr^tm1Avt mutation (0 available); any Ltbr mutation (47 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:158663 )

• died at day 8-12 post-infection with C. rodentium

growth/size/body

weight loss ( J:158663 )

• exhibit weight loss post infection with C. rodentium

immune system

decreased neutrophil cell number ( J:158663 )

• reduced number of neutrophils in the colon lamina propria

abnormal chemokine level ( J:158663 )

• lower expression of CXCL1 and CXCL2 chemokines in the colon lamina propria

increased susceptibility to bacterial infection ( J:158663 )

• display weight loss, increased bacterial titers in the feces and blood and severe colon pathology after infection with Citrobacter rodentium

increased susceptibility to bacterial infection induced morbidity/mortality ( J:158663 )

• died at day 8-12 post-infection with C. rodentium

digestive/alimentary system

abnormal colon morphology ( J:158663 )

• display severe colon pathology post infection with C. rodentium

hematopoietic system

decreased neutrophil cell number ( J:158663 )

• reduced number of neutrophils in the colon lamina propria

homeostasis/metabolism

abnormal chemokine level ( J:158663 )

• lower expression of CXCL1 and CXCL2 chemokines in the colon lamina propria

Allelic Composition	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor^tm1(DTA)Riet Tg(Rorc-cre)1Litt/?
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal effector T cell morphology ( J:137020 )

immune system

abnormal effector T cell morphology ( J:137020 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23