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Allele Symbol Allele Name Allele ID |
Tg(AQP2-cre)2Dek transgene insertion 2, Donald E Kohan MGI:3054057 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice have significantly elevated systolic blood pressure compared to controls as well as Ednra and Ednrb conditional knockout mice on a normal sodium diet
• on a high sodium diet, systolic blood pressure increases significantly compared to controls; change in BP between normal and high sodium diets is much greater than in Ednra or Ednrb conditional mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice do not show significantly increased systolic blood pressure on normal or high sodium diets compared to controls; BP is lower than Ednrb or Edn1 conditional knockouts on either diet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no differences in water intake, urinary osmolyte excretion, urinary urea excretion or arginine vasopressin plasma levels
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• on a high salt diet
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• on a high salt diet
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• modest but significant reduction when fluid intake is similar to controls or whwn under moderate water restriction
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• reduced arginine vasopressin stimulated cAMP accumulation in inner medulla collecting ducts
• magnitude of the decrease in arginine vasopressin stimulated inner medullary cAMP and urinary concentrating ability is similar to mice with conditional deletion of Adcy6 alone
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• urine volume tends to be increased when fluid intake is similar to controls and is significantly increased during moderate and severe water restriction
• urine volume is increased in mice on a high salt diet compared to diet matched controls
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| N |
• blood pressure is similar to controls
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• on a high salt diet
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• on a high salt diet
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• modest but significant reduction when fluid intake is similar to controls or whwn under moderate water restriction
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no difference in renal water and urea excretion compared to controls under baseline, moderate or marked water restriction
• no difference in urine volume, blood pressure or renal sodium handling on a normal salt or high salt diet compared to diet matched controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• on a normal sodium diet, BP is 12.9 mmHg greater than control; on a high sodium diet, BP is additionally increased (+7 mmHg)
• BP is significantly greater than that observed in Ednra conditional mutants, and the additional increase seen with sodium loading is greater than Ednrb mutants but less than Edn1 conditional mutants
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• on a normal sodium diet, BP is 8.9 mmHg greater than control; on a high sodium diet, BP is additionally increased (+5 mmHg)
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• mice have significantly elevated systolic blood pressure compared to controls as well as Ednra and Ednrb condition knockout mice on a normal sodium diet
• on a high sodium diet, systolic blood pressure increases significantly compared to controls; change in BP between normal and high sodium diets is much greater than in Ednra or Ednrb conditional mutants
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• urinary aldosterone excretion is lower than in controls
• on high sodium diet, urinary endothelin excretion is increased 3-fold over mutants on a normal sodium diet
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• after i.p. administration of 1.5 ml normal saline, urinary sodium excretion is substantially reduced in the first 2 hours after sodium loading; no difference is detected at 6 hours
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• on normal sodium diet, plasma renin activity (PRA) is lower (~4-fold) than in controls
• on high sodium diet, PRA is lower (~3-fold) than in controls
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• urinary aldosterone excretion is lower than in controls
• on high sodium diet, urinary endothelin excretion is increased 3-fold over mutants on a normal sodium diet
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• after i.p. administration of 1.5 ml normal saline, urinary sodium excretion is substantially reduced in the first 2 hours after sodium loading; no difference is detected at 6 hours
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• during initial 2 hours after sodium loading, urine output is reduced compared to controls (0.11 ml vs 0.75 ml)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants are hypertensive compared to littermates that do not express cre
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• on a high salt diet systolic blood pressure rises in mutants but not littermate control
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• on a high salt diet decreased Na excretion is seen for the first 3 days in mutants compared to littermate controls
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• on a high salt diet decreased Na excretion is seen for the first 3 days in mutants compared to littermate controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are viable and exhibit normal growth rates and normal kidney histology, with no apparent gross abnormalities
• no differences in vasopressin- or angiotensin II-stimulated cAMP generation in the inner medulla relative to controls
• normal water intake, urine flow, urine osmolality, and urinary osmolyte excretion during normal, moderate, and severe water restriction relative to controls
• no differences in systolic BP, diastolic BP, or heart rate on any of the days during normal-, high- or low-Na feeding relative to controls
• normal sodium intake and urinary Na excretion during normal-, high-, or low-Na diet relative to controls
• normal plasma AVP during normal or low-water diet relative to controls
• normal plasma renin concentration during normal or low-salt diet relative to controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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