Edn1^tm1Ywa
Targeted Allele Detail

Summary

• Symbol: Edn1^tm1Ywa
• Name: endothelin 1; targeted mutation 1, Masashi Yanagisawa
• MGI ID: MGI:3044563
• Synonyms: ET-1^flox
• Gene: Edn1 Location: Chr13:42454952-42461466 bp, + strand Genetic Position: Chr13, 20.82 cM
• Alliance: Edn1^tm1Ywa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90390
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2, and a neo-thymidine kinase selection cassette with a 3' loxP site was inserted downstream of exon 2. Southern blot and RT-PCR indicate presence of recombinant transcript. (J:90390)

Expression

In Mice Carrying this Mutation:	57 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Edn1 Mutation: 25 strains or lines available

References

• Original: J:90390 Shohet RV, et al., Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2088-93
• All: 24 reference(s)