Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn1tm1Ywa mutation
(1 available);
any
Edn1 mutation
(25 available)
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normal phenotype
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• mice grow normally with no detectable abnormalities
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn1tm1Ywa mutation
(1 available);
any
Edn1 mutation
(25 available)
Tg(AQP2-cre)2Dek mutation
(0 available)
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cardiovascular system
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• mice have significantly elevated systolic blood pressure compared to controls as well as Ednra and Ednrb conditional knockout mice on a normal sodium diet
• on a high sodium diet, systolic blood pressure increases significantly compared to controls; change in BP between normal and high sodium diets is much greater than in Ednra or Ednrb conditional mutants
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn1tm1Ywa mutation
(1 available);
any
Edn1 mutation
(25 available)
Tg(Aqp2-cre)1Dek mutation
(1 available)
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homeostasis/metabolism
renal/urinary system
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N |
• mutant and control animals display similar renal function (volume of urine excreted, osmolyte secretion, plasma osmolality, or plasma sodium concentration) under normal and high water intake
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• more urinary excretion of endothelin-1 is seen in mutants over 6 hour period following water loading compared to controls
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• with chronic administration (for 7 days) of 1-desamno-8-D-arginine vasopressin (DDAVP) increases urine osmolality in mutants but not in controls; elevation does not persist past 3 days of DDAVP administration
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• antidiuretic hormone-induced cyclic AMP accumulation is higher in mutant inner medullary collecting ducts than in control tissue
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• mutants show reduced water excretion for up to 3 hours after acute water loading
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn1tm1Ywa mutation
(1 available);
any
Edn1 mutation
(25 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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cardiovascular system
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N |
• mice exhibit normal heart weight and rate
• mice exhibit normal response to acute administration of vasoactive substances (captopril, angiotensin II, phenylephrine or bradykinin)
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• in light and dark phases though less pronounced in the dark phase
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• in light and dark phases
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• in light and dark phases
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embryo
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N |
• mice do not exhibit developmental defects
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn1tm1Ywa mutation
(1 available);
any
Edn1 mutation
(25 available)
Tg(Myh6-cre)2182Mds mutation
(3 available)
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cardiovascular system
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• mice are resistant to hyperthyroid cardiac hypertrophy, showing a 57% reduction in cardiac hypertrophy in response to tri-iodothyronine (T3) relative to control mice
(J:90390)
• left ventricular mass is increased by 3% in response to T3, compared to a 27% increase observed in similarly treated control mice
(J:90390)
• the magnitude of Trypanosoma cruzi infection-associated cardiomyopathy is significantly less than in controls
(J:96386)
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn1tm1Ywa mutation
(1 available);
any
Edn1 mutation
(25 available)
Tg(AQP2-cre)2Dek mutation
(0 available)
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cardiovascular system
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• mutants are hypertensive compared to littermates that do not express cre
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• on a high salt diet systolic blood pressure rises in mutants but not littermate control
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renal/urinary system
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• on a high salt diet decreased Na excretion is seen for the first 3 days in mutants compared to littermate controls
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homeostasis/metabolism
Analysis Tools
