Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(BCL2)36Wehi transgene insertion 36, Walter and Eliza Hall Institute of Medical Research MGI:3052954 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased frequency of aberrations such as polyploidy, quadriradial chromosomes, and telomeric translocations
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| N |
• thymus cellularity restored
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop a more aggressive primitive B cell leukemia by 5 weeks of age than in Tg(IghMyc)22Bri/0 mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit extended median survival time of 113 days compared to 54 days in double Tg(IghMyc)22Bri/0 and Tg(BCL2)36Wehi/0 transgenic mice
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• mice eventually develop leukemia
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• mice eventually develop leukemia and die but later than Tg(IghMyc)22Bri/0 mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the decrease in the number of follicular B cells is not corrected by the presence of the transgene
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• the decrease in the number of follicular B cells is not corrected by the presence of the transgene
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a few mice develop fatal clonal T cell tumors
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• mutants show an excess of B lymphocytes
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• mutants have an excess of T lymphocytes
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• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes
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• mice display increased serum immunoglobulin concentrations
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• transgenic T cells show prolonged in vitro survival in culture compared to wild-type T lymphocytes
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• a few mice develop fatal clonal T cell tumors
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• mutants show an excess of B lymphocytes
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• mutants have an excess of T lymphocytes
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• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes
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• mice display increased serum immunoglobulin concentrations
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• transgenic T cells show prolonged in vitro survival in culture compared to wild-type T lymphocytes
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• some transgenic mice develop a systemic autoimmune-like disease
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• a few mice develop fatal clonal T cell tumors
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• a few mice develop fatal clonal T cell tumors
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
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• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls
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• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
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• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls
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• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
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• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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