Phenotypes associated with this allele
cellular
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• increased frequency of aberrations such as polyploidy, quadriradial chromosomes, and telomeric translocations
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immune system
N |
• thymus cellularity restored
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation
(0 available);
any
Pik3cd mutation
(43 available)
Tg(BCL2)36Wehi mutation
(3 available)
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immune system
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• the decrease in the number of follicular B cells is not corrected by the presence of the transgene
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hematopoietic system
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• the decrease in the number of follicular B cells is not corrected by the presence of the transgene
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Allelic Composition |
Tg(BCL2)36Wehi/0
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Genetic Background |
involves: C57BL/6JWehi * SJL/JWehi |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)36Wehi mutation
(3 available)
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hematopoietic system
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• mutants show an excess of B lymphocytes
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• mutants have an excess of T lymphocytes
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• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes
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• mice display increased serum immunoglobulin concentrations
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• transgenic T cells show prolonged in vitro survival in culture compared to wild-type T lymphocytes
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immune system
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• mutants show an excess of B lymphocytes
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• mutants have an excess of T lymphocytes
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• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes
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• mice display increased serum immunoglobulin concentrations
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• transgenic T cells show prolonged in vitro survival in culture compared to wild-type T lymphocytes
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• some transgenic mice develop a systemic autoimmune-like disease
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neoplasm
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• a few mice develop fatal clonal T cell tumors
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endocrine/exocrine glands
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• a few mice develop fatal clonal T cell tumors
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)36Wehi mutation
(3 available)
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hematopoietic system
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• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
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• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls
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immune system
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• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
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• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls
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cellular
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• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
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• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls
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