About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Disp1tm1Amc
targeted mutation 1, Andrew P McMahon
MGI:3052133
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Disp1tm1Amc/Disp1tm1Amc involves: 129X1/SvJ MGI:3052722
ht2
 		Disp1icb/Disp1tm1Amc involves: 129X1/SvJ * C57BL/6J MGI:3052725
cn3
 		Disp1icb/Disp1tm1Amc
Shhtm1(EGFP/cre)Cjt/Shh+ 		involves: 129X1/SvJ * C57BL/6J MGI:3054017
cx4
 		Disp1tm1Amc/Disp1tm1Amc
Ptch1tm1Mps/Ptch1+ 		involves: 129S1/Sv * 129X1/SvJ MGI:3052724
cx5
 		Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+ 		involves: 129X1/SvJ * C57BL/6J MGI:3052728


Genotype
MGI:3052722
hm1
Allelic
Composition		 Disp1tm1Amc/Disp1tm1Amc
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1tm1Amc mutation (0 available); any Disp1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:92058 )
• die at birth, difficulty breathing

growth/size/body
abnormal facial morphology ( J:92058 )
• mild midline facial defects involving the nose and upper jaw
absent upper incisors ( J:92058 )
• loss of upper incisors
philtrum hypoplasia ( J:92058 )
• hypoplastic philtrum
absent primary palate ( J:92058 )
• loss of primary palate
abnormal vomeronasal organ morphology ( J:92058 )
• fused vomeronasal organs

craniofacial
abnormal facial morphology ( J:92058 )
• mild midline facial defects involving the nose and upper jaw
absent upper incisors ( J:92058 )
• loss of upper incisors
philtrum hypoplasia ( J:92058 )
• hypoplastic philtrum
absent primary palate ( J:92058 )
• loss of primary palate
abnormal vomeronasal organ morphology ( J:92058 )
• fused vomeronasal organs

respiratory system
abnormal vomeronasal organ morphology ( J:92058 )
• fused vomeronasal organs
abnormal nasopharynx morphology ( J:92058 )
• nasopharyngeal airway narrowed or closed
respiratory distress ( J:92058 )
• difficulty breathing at birth leading to death

endocrine/exocrine glands

vision/eye
ocular hypotelorism ( J:92058 )
• eyes positioned near the midline

nervous system
abnormal vomeronasal organ morphology ( J:92058 )
• fused vomeronasal organs
abnormal neuron specification ( J:92058 )
• 40% reduction of progenitor V3 population

skeleton
absent upper incisors ( J:92058 )
• loss of upper incisors

digestive/alimentary system
absent primary palate ( J:92058 )
• loss of primary palate




Genotype
MGI:3052725
ht2
Allelic
Composition		 Disp1icb/Disp1tm1Amc
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (61 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
absent primary palate ( J:92058 )
• loss of primary palate

craniofacial
abnormal basisphenoid bone morphology ( J:92058 )
• misshapen or absent
absent basisphenoid bone ( J:92058 )
• misshapen or absent
abnormal occipital bone morphology ( J:92058 )
• misshapen or absent
absent occipital bone ( J:92058 )
• misshapen or absent
abnormal viscerocranium morphology ( J:92058 )
• loss of primary palate, premaxillary and nasal components
abnormal frontal bone morphology ( J:92058 )
• severe losses of frontal component
absent upper incisors ( J:92058 )
• loss of upper incisors
absent primary palate ( J:92058 )
• loss of primary palate
absent vomeronasal organ ( J:92058 )
• lack vomeronasal organs

endocrine/exocrine glands
absent pituitary gland ( J:92058 )
• failed to develop

respiratory system
absent vomeronasal organ ( J:92058 )
• lack vomeronasal organs
abnormal nasopharynx morphology ( J:92058 )
• nasopharyngeal airway narrowed or closed

skeleton
abnormal basisphenoid bone morphology ( J:92058 )
• misshapen or absent
absent basisphenoid bone ( J:92058 )
• misshapen or absent
abnormal occipital bone morphology ( J:92058 )
• misshapen or absent
absent occipital bone ( J:92058 )
• misshapen or absent
abnormal viscerocranium morphology ( J:92058 )
• loss of primary palate, premaxillary and nasal components
abnormal frontal bone morphology ( J:92058 )
• severe losses of frontal component
absent upper incisors ( J:92058 )
• loss of upper incisors
delayed chondrocyte differentiation ( J:92058 )
• delayed differentiation in the cervical region

nervous system
absent vomeronasal organ ( J:92058 )
• lack vomeronasal organs
absent pituitary gland ( J:92058 )
• failed to develop

growth/size/body
abnormal head morphology ( J:92058 )
• severe midline facial defects by E10.5
abnormal viscerocranium morphology ( J:92058 )
• loss of primary palate, premaxillary and nasal components
absent basisphenoid bone ( J:92058 )
• misshapen or absent
abnormal frontal bone morphology ( J:92058 )
• severe losses of frontal component
absent upper incisors ( J:92058 )
• loss of upper incisors
absent primary palate ( J:92058 )
• loss of primary palate
absent vomeronasal organ ( J:92058 )
• lack vomeronasal organs




Genotype
MGI:3054017
cn3
Allelic
Composition		 Disp1icb/Disp1tm1Amc
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (61 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (61 available)
Shhtm1(EGFP/cre)Cjt mutation (2 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
oligodactyly ( J:92504 )
• digit 2 is absent, all other digits are present




Genotype
MGI:3052724
cx4
Allelic
Composition		 Disp1tm1Amc/Disp1tm1Amc
Ptch1tm1Mps/Ptch1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1tm1Amc mutation (0 available); any Disp1 mutation (61 available)
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:92058 )
• viable fertile, and outwardly normal

nervous system
nervous system phenotype ( J:92058 )
N
• normal floor plate and progenitor/precursor neuron patterning




Genotype
MGI:3052728
cx5
Allelic
Composition		 Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (61 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (61 available)
Shhtm1Amc mutation (1 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
failure of heart looping ( J:92058 )
• no heart looping but normal embryo turning

nervous system
abnormal neuron specification ( J:92058 )
• ventral midline of neural tube occupied by a reduced population of motor neuron progenitors

craniofacial
proboscis ( J:92058 )
• extreme proboscis-like nasal process

growth/size/body
proboscis ( J:92058 )
• extreme proboscis-like nasal process

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
holoprosencephaly 3 DOID:0110875 OMIM:142945
 J:92058




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory