Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St8sia2tm1Jxm mutation
(1 available);
any
St8sia2 mutation
(23 available)
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behavior/neurological
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• mutants fail to increase their latency to enter the dark chamber in a passive avoidance task
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• impaired performance in a contextual fear conditioning test is seen
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• impaired performance in a cued fear conditioning test is seen, however, the acoustic startle response is normal
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• mutants are more active in the open field test, spend more time in the center of the field, and rear more frequently, however, mutants are not hyperactive
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nervous system
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• abnormal mossy fibers on the ventral side of the granule cell layer are associated with ectopic synapses
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• the infrapyramidal mossy fibers extend into the faeCA3a region and into the CA3b and CA3c regionsfrom the age of 2 weeks on
• mossy fibers also extend along the ventral side of the granule cell layer
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St8sia2tm1Jxm mutation
(1 available);
any
St8sia2 mutation
(23 available)
St8sia4tm1.1Mifu mutation
(0 available);
any
St8sia4 mutation
(26 available)
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mortality/aging
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• most mice die between P0 and P10 with some mice surviving until P20
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nervous system
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• neurons and their precursors in the cortex and subventricular zone undergo more apoptosis than in wild-type mice
• however, hippocampal cells do not undergo apoptosis except for those located in the lateral ventricle
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• in culture, neurospheres differentiate into GFAP+ cells that have astrocyte-like morphology unlike wild-type neurospehre cells
• in the presence of PDGF more neurospheres differentiated into GFAP+ cells (47.0+/-1.5% compared to 31.6+/-4.8% of wild-type neurospheres) while in the presence of BDNF fewer do so (21.6+/-5.8% compared to 25.6+/-5.2 of wild-type neurospheres)
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• neuron migration is impaired and in culture neurons move 8 to 15% slower than wild-type neurons when plated on laminin
• however, proliferation and differentiation of neurons is normal
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• at P0 the rostral migratory stream is thicker than in wild-type mice but by P10 it is thinner than in wild-type mice
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• GABAnergic interneurons in the cerebral cortex are decreased to 20% of the number found in wild-type mice
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• hippocampal cells located in the lateral ventricle undergo apoptosis
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• coronal and sagittal brain sections reveal an increase in the size of the lateral ventricle as well as a thinner cortex
• lateral ventricles increase with age
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• the corpus callosum is thinner than in wild-type mice or partially absent
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• the striatum is thinner than in wild-type mice
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• the diencephalons is thinner than in wild-type mice
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• hippocampal cells located in the lateral ventricle undergo apoptosis
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• mice have fewer cortical cells than in wild-type mice
• neurons and their precursors in the cortex and subventricular zone undergo more apoptosis than in wild-type mice
• GABAnergic interneurons in the cerebral cortex are decreased to 20% of the number found in wild-type mice
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• in layers II/III and IV of the neocortex
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• unlike in wild-type mice, pyramidal cells are detected in the subventricular zone
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• coronal and sagittal brain sections reveal an increase in the size of the lateral ventricle as well as a thinner cortex
• the cerebral cortex becomes thinner with age
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• at P10, the olfactory bulb is smaller than in wild-type mice due to impaired movement of neuroblasts from the sub-ventricular zone to the olfactory bulb
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• neurons and their precursors in the cortex and subventricular zone undergo more apoptosis than in wild-type mice
• unlike in wild-type mice, pyramidal cells are detected in the subventricular zone
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• glial cell migration is impaired whereby GFAP+ cells are confined to the subventricular zone close to the lateral ventricle
• unlike in wild-type mice, GFAP+ cells exhibit an elongated morphology
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• the number of GFAP+ astrocytes in the hippocampus is decreased to 30% of wild-type hippocampus
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behavior/neurological
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• mice exhibit slow, weak and uncoordinated movements
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growth/size/body
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• mice are smaller than normal
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cellular
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• neurons and their precursors in the cortex and subventricular zone undergo more apoptosis than in wild-type mice
• however, hippocampal cells do not undergo apoptosis except for those located in the lateral ventricle
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• in culture, neurospheres differentiate into GFAP+ cells that have astrocyte-like morphology unlike wild-type neurospehre cells
• in the presence of PDGF more neurospheres differentiated into GFAP+ cells (47.0+/-1.5% compared to 31.6+/-4.8% of wild-type neurospheres) while in the presence of BDNF fewer do so (21.6+/-5.8% compared to 25.6+/-5.2 of wild-type neurospheres)
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• neuron migration is impaired and in culture neurons move 8 to 15% slower than wild-type neurons when plated on laminin
• however, proliferation and differentiation of neurons is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St8sia2tm1Jxm mutation
(1 available);
any
St8sia2 mutation
(23 available)
St8sia4tm1.1Mifu mutation
(0 available);
any
St8sia4 mutation
(26 available)
Tg(Thy1-YFP)HJrs mutation
(3 available)
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nervous system
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• unlike in wild-type mice, the projections of dendrites and axons from pyramidal cells are disorganized
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• the number of pyramidal cells is decreased to 25% of that in wild-type mice
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Analysis Tools