Phenotypes associated with this allele

• Allele Symbol: Scrib⁺
• Allele Name: wild type
• Allele ID: MGI:3049513
• Summary: 15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Scrib^Crc/Scrib^+	C3H.Cg-Scrib^Crc	MGI:5661729
ht2	Scrib^tm1b(NCOM)Mfgc/Scrib^+	C57BL/6N-Scrib^tm1a(NCOM)Mfgc/Tcp	MGI:5797793
ht3	Scrib^Crc/Scrib^+	involves: BALB/c * C57BL/6 * NMRI	MGI:3619997
ht4	Scrib^Crc/Scrib^+	involves: C57BL/6J * NMRI	MGI:4415139
ht5	Scrib^tm1.2Phum/Scrib^+	involves: FVB/N	MGI:5300207
cn6	Kras^tm4Tyj/Kras^+ Scrib^tm1.1Phum/Scrib^+	involves: 129S4/SvJae	MGI:5638047
cn7	Kras^tm4Tyj/Kras^+ Scrib^tm1.1Phum/Scrib^+ Tg(Pbsn-cre)20Fwan/0	involves: 129S4/SvJae * FVB/NCrl	MGI:5300205
cx8	Celsr1^Crsh/Celsr1^+ Scrib^Crc/Scrib^+	C3H.Cg-Scrib^Crc Celsr1^Crsh	MGI:5661818
cx9	Celsr1^Scy/Celsr1^+ Scrib^Crc/Scrib^+	C3H.Cg-Scrib^Crc Celsr1^Scy	MGI:5661820
cx10	Scrib^Crc/Scrib^+ Vangl2^Lp/Vangl2^+	C3H.Cg-Vangl2^Lp Scrib^Crc	MGI:5661815
cx11	Celsr1^Crsh/Celsr1^+ Scrib^Crc/Scrib^+ Vangl2^Lp/Vangl2^+	C3H.Cg-Vangl2^Lp Scrib^Crc Celsr1^Crsh	MGI:5661822
cx12	Celsr1^Crsh/Celsr1^+ Scrib^Crc/Scrib^+	involves: 101/H * BALB/c * C3H/HeH * C57BL/6 * NMRI	MGI:5661724
cx13	Scrib^crn2/Scrib^+ Vangl2^Lp/Vangl2^+	involves: A/J * FVB/N	MGI:5056406
cx14	Scrib^Crc/Scrib^+ Vangl2^+/Vangl2^Lp	involves: BALB/c * C57BL/6 * CBA/Ca * LPT/LeJ * NMRI * SWR	MGI:3797053
cx15	Scrib^m51206BHubr/Scrib^+ Sec24b^krb/Sec24b^krb	involves: C57BL/6 * FVB/N	MGI:4440753

Genotype
MGI:5661729

ht1

• Allelic Composition: Scrib^Crc/Scrib⁺
• Genetic Background: C3H.Cg-Scrib^Crc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:216413 )

N • embryos initiate neural tube closure similarly to wild-type embryos

Genotype
MGI:5797793

ht2

• Allelic Composition: Scrib^{tm1b(NCOM)Mfgc}/Scrib⁺
• Genetic Background: C57BL/6N-Scrib^{tm1a(NCOM)Mfgc}/Tcp
• Cell Lines: M00024_C_366W_A11

Data Sources

IMPC Data for Scrib

behavior/neurological

abnormal gait ( J:211773 )

♀

IMPC - TCP

homeostasis/metabolism

increased circulating triglyceride level ( J:211773 )

IMPC - TCP

vision/eye

abnormal retina morphology ( J:211773 )

♀

IMPC - TCP

Genotype
MGI:3619997

ht3

• Allelic Composition: Scrib^Crc/Scrib⁺
• Genetic Background: involves: BALB/c * C57BL/6 * NMRI

limbs/digits/tail

curly tail ( J:62635 )

• in some mice, tail defect appears as a complete looping or circling of tail

• defect appears 10 fold more frequently in males

kinked tail ( J:62635 )

• in some mice, tail defect appears as a bend or kink in middle portion

• defect appears 10 fold more frequently in males

Genotype
MGI:4415139

ht4

• Allelic Composition: Scrib^Crc/Scrib⁺
• Genetic Background: involves: C57BL/6J * NMRI

limbs/digits/tail

curly tail ( J:77245 )

• incomplete penetrance (about 5%) of circled-tail, almost exclusively in males

Genotype
MGI:5300207

ht5

• Allelic Composition: Scrib^tm1.2Phum/Scrib⁺
• Genetic Background: involves: FVB/N

Prostate hyperplasia in Scrib^tm1.2Phum/Scrib⁺ mice

reproductive system

increased prostate gland weight ( J:178461 )

♂ • however, treatment with MEK inhibitor PD0325901 restores normal prostate weight

prostate gland hyperplasia ( J:178461 )

♂ • in 7 of 10 mice with a 4.8-fold increase in cell proliferation without a change in the rate of apoptosis

abnormal prostate gland physiology ( J:178461 )

♂ • a 4.8-fold increase in cell proliferation without a change in the rate of apoptosis

neoplasm

increased lung adenoma incidence ( J:216266 )

• 43% incidence of lung adenomas by 540 days of age

• lung tumors range from atypical adenomatous hyperplasia to focal grade 3 lesions

increased lung non-small cell carcinoma incidence ( J:216266 )

• lung adenomas have characteristics of non-small cell lung cancer

increased lung adenocarcinoma incidence ( J:178461 )

• at 540 days, 4 of 8 mice develop lung adenocarcinomas unlike wild-type mice

endocrine/exocrine glands

increased prostate gland weight ( J:178461 )

♂ • however, treatment with MEK inhibitor PD0325901 restores normal prostate weight

prostate gland hyperplasia ( J:178461 )

♂ • in 7 of 10 mice with a 4.8-fold increase in cell proliferation without a change in the rate of apoptosis

abnormal pancreas morphology ( J:178461 )

• at 540 days, one mouse exhibit pancreatic preinvasive ductal lesions unlike wild-type mice

abnormal prostate gland physiology ( J:178461 )

♂ • a 4.8-fold increase in cell proliferation without a change in the rate of apoptosis

respiratory system

increased lung adenoma incidence ( J:216266 )

• 43% incidence of lung adenomas by 540 days of age

• lung tumors range from atypical adenomatous hyperplasia to focal grade 3 lesions

increased lung non-small cell carcinoma incidence ( J:216266 )

• lung adenomas have characteristics of non-small cell lung cancer

increased lung adenocarcinoma incidence ( J:178461 )

• at 540 days, 4 of 8 mice develop lung adenocarcinomas unlike wild-type mice

Genotype
MGI:5638047

cn6

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Scrib^tm1.1Phum/Scrib⁺
• Genetic Background: involves: 129S4/SvJae

neoplasm

increased lung tumor incidence ( J:216266 )

• 83% of mice develop tumors ranging from grades 1 to 3 at 6 weeks post intranasal adenoviral cre (AdCre) administration

respiratory system

increased lung tumor incidence ( J:216266 )

• 83% of mice develop tumors ranging from grades 1 to 3 at 6 weeks post intranasal adenoviral cre (AdCre) administration

lung epithelium hyperplasia ( J:216266 )

• 100% of mice show epithelial hyperplasia at 6 weeks post intranasal AdCre administration

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:216266

Genotype
MGI:5300205

cn7

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Scrib^tm1.1Phum/Scrib⁺; Tg(Pbsn-cre)20Fwan/0
• Genetic Background: involves: 129S4/SvJae * FVB/NCrl

reproductive system

increased prostate gland adenocarcinoma incidence ( J:178461 )

♂ • well-differentiated adenocarcinomas in 13% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

♂ • high-grade in 20% of mice

abnormal prostate gland physiology ( J:178461 )

♂ • increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

neoplasm

increased prostate gland adenocarcinoma incidence ( J:178461 )

♂ • well-differentiated adenocarcinomas in 13% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

♂ • high-grade in 20% of mice

digestive/alimentary system

abnormal intestine morphology ( J:178461 )

• focal intestinal metaplasia

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:178461 )

♂ • well-differentiated adenocarcinomas in 13% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

♂ • high-grade in 20% of mice

abnormal prostate gland physiology ( J:178461 )

♂ • increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

Genotype
MGI:5661818

cx8

• Allelic Composition: Celsr1^Crsh/Celsr1⁺; Scrib^Crc/Scrib⁺
• Genetic Background: C3H.Cg-Scrib^Crc Celsr1^Crsh

embryo

abnormal developmental patterning ( J:216413 )

• skewed body axis in some mutants

spina bifida ( J:216413 )

• lumbosacral open spina bifida in 2% of mutants (1 of 41); this mouse shows partially closed eyelids

craniorachischisis ( J:216413 )

• 42% of mutants exhibit craniorachischisis, most often isolated (32% of mutants) but sometimes associated with abdominal wall defect and a skewed body axis (10% of mutants)

• however, 46% of mutants appear normal

growth/size/body

abnormal abdominal wall morphology ( J:216413 )

• abdominal wall defect in some mutants

limbs/digits/tail

curly tail ( J:216413 )

• 2% of mutants exhibit a looped tail

nervous system

spina bifida ( J:216413 )

• lumbosacral open spina bifida in 2% of mutants (1 of 41); this mouse shows partially closed eyelids

craniorachischisis ( J:216413 )

• 42% of mutants exhibit craniorachischisis, most often isolated (32% of mutants) but sometimes associated with abdominal wall defect and a skewed body axis (10% of mutants)

• however, 46% of mutants appear normal

exencephaly ( J:216413 )

• isolated exencephaly in 7% of mutants

vision/eye

abnormal eyelid morphology ( J:216413 )

• mutants with craniorachischisis show completely open eyelids at E16.5

abnormal eyelid development ( J:216413 )

• 50% of mutants (5 of 10) exhibit failure of eyelid formation at E16.5

• mutants with craniorachischisis show completely open eyelids

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neural tube defect		DOID:0080074	OMIM:301410 OMIM:601634	J:216413

Genotype
MGI:5661820

cx9

• Allelic Composition: Celsr1^Scy/Celsr1⁺; Scrib^Crc/Scrib⁺
• Genetic Background: C3H.Cg-Scrib^Crc Celsr1^Scy

embryo

craniorachischisis ( J:216413 )

• 62% mutants exhibit craniorachischisis, most often isolated (in 56% of mutants), but sometimes associated with abdominal wall defect (6% of mutants)

• however, 39% mutants appear normal

growth/size/body

abnormal abdominal wall morphology ( J:216413 )

• 1 of 18 mutants with craniorachischisis show an abdominal wall defect

nervous system

craniorachischisis ( J:216413 )

• 62% mutants exhibit craniorachischisis, most often isolated (in 56% of mutants), but sometimes associated with abdominal wall defect (6% of mutants)

• however, 39% mutants appear normal

vision/eye

abnormal eyelid morphology ( J:216413 )

• some mutants with craniorachischisis show eyelid closure defects

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neural tube defect		DOID:0080074	OMIM:301410 OMIM:601634	J:216413

Genotype
MGI:5661815

cx10

• Allelic Composition: Scrib^Crc/Scrib⁺; Vangl2^Lp/Vangl2⁺
• Genetic Background: C3H.Cg-Vangl2^Lp Scrib^Crc

embryo

abnormal developmental patterning ( J:216413 )

• skewed body axis in some mutants

craniorachischisis ( J:216413 )

• 81% of mutants exhibit craniorachischisis, most often isolated (in 50% of mutants) but sometimes associated with abdominal wall defect (in 31% of mutants) and a skewed body axis

growth/size/body

abnormal abdominal wall morphology ( J:216413 )

• 3% of mutants exhibit only an abdominal wall defect while 31% exhibit both abdominal wall defect and craniorachischisis

limbs/digits/tail

curly tail ( J:216413 )

• 6% of mutants exhibit a looped tail

mortality/aging

prenatal lethality, incomplete penetrance ( J:216413 )

• 13% of mutants are viable postnatally

nervous system

craniorachischisis ( J:216413 )

• 81% of mutants exhibit craniorachischisis, most often isolated (in 50% of mutants) but sometimes associated with abdominal wall defect (in 31% of mutants) and a skewed body axis

exencephaly ( J:216413 )

• 3% of mutants exhibit exencephaly

vision/eye

abnormal eyelid morphology ( J:216413 )

• all mutants exhibit failure of eyelid closure at E16.5; all these have craniorachischisis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neural tube defect		DOID:0080074	OMIM:301410 OMIM:601634	J:216413

Genotype
MGI:5661822

cx11

• Allelic Composition: Celsr1^Crsh/Celsr1⁺; Scrib^Crc/Scrib⁺; Vangl2^Lp/Vangl2⁺
• Genetic Background: C3H.Cg-Vangl2^Lp Scrib^Crc Celsr1^Crsh

embryo

craniorachischisis ( J:216413 )

• 2 of 3 mutants exhibit craniorachischisis

limbs/digits/tail

abnormal tail morphology ( J:216413 )

• 1 of 3 mice exhibits hindbrain exencephaly and a tail defect

nervous system

craniorachischisis ( J:216413 )

• 2 of 3 mutants exhibit craniorachischisis

exencephaly ( J:216413 )

• 1 of 3 mice exhibits hindbrain exencephaly and a tail defect

Genotype
MGI:5661724

cx12

• Allelic Composition: Celsr1^Crsh/Celsr1⁺; Scrib^Crc/Scrib⁺
• Genetic Background: involves: 101/H * BALB/c * C3H/HeH * C57BL/6 * NMRI

embryo

craniorachischisis ( J:216413 )

• 8% of embryos develop craniorachischisis

nervous system

craniorachischisis ( J:216413 )

• 8% of embryos develop craniorachischisis

Genotype
MGI:5056406

cx13

• Allelic Composition: Scrib^crn2/Scrib⁺; Vangl2^Lp/Vangl2⁺
• Genetic Background: involves: A/J * FVB/N

nervous system

craniorachischisis ( J:174027 )

• show either craniorachischisis or loop tail

embryo

craniorachischisis ( J:174027 )

• show either craniorachischisis or loop tail

limbs/digits/tail

curly tail ( J:174027 )

• show either craniorachischisis or loop tail

Genotype
MGI:3797053

cx14

• Allelic Composition: Scrib^Crc/Scrib⁺; Vangl2⁺/Vangl2^Lp
• Genetic Background: involves: BALB/c * C57BL/6 * CBA/Ca * LPT/LeJ * NMRI * SWR

nervous system

spina bifida ( J:72608 )

craniorachischisis ( J:72608 )

• 29 of 54 double heterozygotes exhibit craniorachisichisis and the remainder had either spina bifida or a looped tail

limbs/digits/tail

curly tail ( J:72608 )

• in a small minority of double heterozygotes

embryo

spina bifida ( J:72608 )

craniorachischisis ( J:72608 )

• 29 of 54 double heterozygotes exhibit craniorachisichisis and the remainder had either spina bifida or a looped tail

Genotype
MGI:4440753

cx15

• Allelic Composition: Scrib^m51206BHubr/Scrib⁺; Sec24b^krb/Sec24b^krb
• Genetic Background: involves: C57BL/6 * FVB/N

hearing/vestibular/ear

abnormal organ of Corti morphology ( J:158680 )

• the organ of Corti is decreased in length compared to in wild-type mice

• at E17.5, the organ of Corti is disorganized unlike in wild-type mice

abnormal cochlear inner hair cell morphology ( J:158680 )

• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice

• mice exhibit a more severe phenotype compared with Sec24b^krb homozygotes

abnormal cochlear outer hair cell morphology ( J:158680 )

• mice exhibit supernumerary rows of outer hair cells unlike wild-type mice

abnormal orientation of outer hair cell stereociliary bundles ( J:158680 )

nervous system

abnormal cochlear inner hair cell morphology ( J:158680 )

• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice

• mice exhibit a more severe phenotype compared with Sec24b^krb homozygotes

abnormal cochlear outer hair cell morphology ( J:158680 )

• mice exhibit supernumerary rows of outer hair cells unlike wild-type mice

abnormal orientation of outer hair cell stereociliary bundles ( J:158680 )