Phenotypes associated with this allele

• Allele Symbol: Dnd1⁺
• Allele Name: wild type
• Allele ID: MGI:3048380
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dnd1^tm1Na/Dnd1^+	129S1.129S6-Dnd1^tm1Na	MGI:5696095
ht2	Dnd1^Ter/Dnd1^+	129S1/Sv-Kit^W Oca2^p Tyr^c-ch	MGI:3690451
ht3	Dnd1^Ter/Dnd1^+	involves: 129P3/J	MGI:5696098
ht4	Dnd1^Ter/Dnd1^+	involves: 129S1/Sv * C57BL/6	MGI:3690453
cx5	Apc^Min/Apc^+ Dnd1^Ter/Dnd1^+	involves: 129P3/J * C57BL/6J	MGI:5696099

Genotype
MGI:5696095

ht1

• Allelic Composition: Dnd1^tm1Na/Dnd1⁺
• Genetic Background: 129S1.129S6-Dnd1^tm1Na

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:221231 )

• 68% of expected heterozygotes in adults

• no homozygotes present

embryonic lethality, incomplete penetrance ( J:221231 )

• no homozygotes found at E3.5

• significantly reduced number of heterozygotes present at E3.5

• reduction in heterozygotes not found in backcrosses

reproductive system

reproductive system phenotype ( J:221231 )

N • litter size is normal despite genotype deficiencies

N • testis weight and germ cell numbers normal

neoplasm

neoplasm ( J:221231 )

N • rate of testicular germ cell tumors similar to controls

Genotype
MGI:3690451

ht2

• Allelic Composition: Dnd1^Ter/Dnd1⁺
• Genetic Background: 129S1/Sv-Kit^W Oca2^p Tyr^c-ch

neoplasm

increased testicular teratoma incidence ( J:7954 )

♂ • 17% (20/117) of males show testicular teratomas, only 2/117 have bilateral teratomas

endocrine/exocrine glands

increased testicular teratoma incidence ( J:7954 )

♂ • 17% (20/117) of males show testicular teratomas, only 2/117 have bilateral teratomas

reproductive system

increased testicular teratoma incidence ( J:7954 )

♂ • 17% (20/117) of males show testicular teratomas, only 2/117 have bilateral teratomas

Genotype
MGI:5696098

ht3

• Allelic Composition: Dnd1^Ter/Dnd1⁺
• Genetic Background: involves: 129P3/J

neoplasm

increased testis tumor incidence ( J:221231 )

• testicular germ cell tumor rate about 39%

reproductive system

increased testis tumor incidence ( J:221231 )

• testicular germ cell tumor rate about 39%

endocrine/exocrine glands

increased testis tumor incidence ( J:221231 )

• testicular germ cell tumor rate about 39%

Genotype
MGI:3690453

ht4

• Allelic Composition: Dnd1^Ter/Dnd1⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

reproductive system

decreased germ cell number ( J:7954 )

• 23% (29/126) of mice from N1 heterozygotes bred to 129/Sv-Dnd1^Ter heterozygotes are germ cell deficient; 29% (28/101) of mice from N2 heterozygotes bred to 129/Sv-Dnd1^Ter heterozygotes are germ cell deficient

• N1 intercrossing results in 20/100 offspring have germ cell deficiency

small ovary ( J:7954 )

♀ • seen in some mice of N3 backcross to B6

small testis ( J:7954 )

♂ • seen in some mice of N3 backcross to B6

increased testis tumor incidence ( J:7954 )

♂ • Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants

increased testicular teratoma incidence ( J:7954 )

♂ • Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants

neoplasm

increased testis tumor incidence ( J:7954 )

♂ • Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants

increased testicular teratoma incidence ( J:7954 )

♂ • Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants

endocrine/exocrine glands

small ovary ( J:7954 )

♀ • seen in some mice of N3 backcross to B6

small testis ( J:7954 )

♂ • seen in some mice of N3 backcross to B6

increased testis tumor incidence ( J:7954 )

♂ • Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants

increased testicular teratoma incidence ( J:7954 )

♂ • Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants

cellular

decreased germ cell number ( J:7954 )

• 23% (29/126) of mice from N1 heterozygotes bred to 129/Sv-Dnd1^Ter heterozygotes are germ cell deficient; 29% (28/101) of mice from N2 heterozygotes bred to 129/Sv-Dnd1^Ter heterozygotes are germ cell deficient

• N1 intercrossing results in 20/100 offspring have germ cell deficiency

Genotype
MGI:5696099

cx5

• Allelic Composition: Apc^Min/Apc⁺; Dnd1^Ter/Dnd1⁺
• Genetic Background: involves: 129P3/J * C57BL/6J

neoplasm

increased intestinal adenoma incidence ( J:221231 )

• 1.5X increase in intestinal tumor rate relative to Apc single heterozygotes

• significantly elevated polyp mass

digestive/alimentary system

increased intestinal adenoma incidence ( J:221231 )

• 1.5X increase in intestinal tumor rate relative to Apc single heterozygotes

• significantly elevated polyp mass