Analysis Tools|
Allele Symbol Allele Name Allele ID |
Chn1+ wild type MGI:3048172 |
||||||||||||||||||||
| Summary |
4 genotypes
|
|
|
Data Sources
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
IMPC - JAX
|
|
IMPC - JAX
|
|
IMPC - JAX
|
 |
IMPC - JAX
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 61.3% penetrance of unilateral or bilateral globe retraction
|
|
• 21% reduction in abducens nerve exiting bundles from its hindbrain exit to the orbit at E11.5
|
|
• embryos show an absence or thinning of the abducens nerve at the primitive extraocular muscle anlage at the orbit, as seen by a reduction in abducens nerve diameter near the orbit
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• synchronous hind limb movement, rabbit like hopping gait
|
|
• increased number of lumbar region interneurons cross the midline
|
|
• shallow, broader, dorsal funiculus
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• while embryos show normalized abducens exit and fasciculation, abducens nerve stalling is increased in the abducens fasciculation region, with both reduced abducens nerve length and thinner nerve diameter near the orbit
• stalled projections do not stay within normal nerve boundaries and instead wander to track with the mandibular and cervical branches of the facial nerve
|
|
• abducens nerve length is reduced in embryos and nerve diameter is thinner near the orbit
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 01/20/2026 MGI 6.24 |
|
|
|
||
