Chn1^tm1.2Ece
Targeted Allele Detail

Summary

• Symbol: Chn1^tm1.2Ece
• Name: chimerin 1; targeted mutation 1.2, Elizabeth C Engle
• MGI ID: MGI:6406376
• Synonyms: Chn1^KO
• Gene: Chn1 Location: Chr2:73441004-73605690 bp, - strand Genetic Position: Chr2, 43.78 cM
• Alliance: Chn1^tm1.2Ece page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243785
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a loxP-flanked exon 3 in which an A to T missense change at position 60 was introduced in exon 3, resulting in a leucine to phenylalanine substitution at amino acid 20 (L20F). An FRT-flanked neomycin selection cassette that was inserted upstream of exon 3 was removed via Flp-mediated recombination. Cre-mediated recombination deleted exon 3. (J:243785)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chn1 Mutation: 44 strains or lines available

References

• Original: J:243785 Nugent AA, et al., Mutant alpha2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome. J Clin Invest. 2017 May 01;127(5):1664-1682
• All: 1 reference(s)