Analysis Tools
mortality/aging
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• not all mice survive beyond weaning
(J:146176)
• fewer than expected mice survive beyond weaning
(J:146743)
|
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• median lifespan of 52.3 weeks, most mice succumb to lymphomas by week 58, and all mice are dead by 100 weeks
(J:146176)
• by 32 weeks of age 50% of mice die whereas all wild-type mice are alive
(J:146743)
• by 64 weeks 94% of mice die whereas all wild-type mice are alive
(J:146743)
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• some mice do not survive beyond weaning
(J:146176)
• fewer than expected mice survive the first 4 days after birth
(J:146743)
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cardiovascular system
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• at E12.5
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• primarily involving the left ventricular free wall and septum
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• primarily involving the left ventricular free wall and septum
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hemorrhage
(
J:146176
)
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• at E12.5
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myocarditis
(
J:146743
)
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• in 57% of mice primarily involving the left ventricular free wall and septum
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respiratory system
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• discolored
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• 20% of mice exhibit lung alterations including interstitial pneumonia, alveolar hemorrhage, and alveolar edema
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liver/biliary system
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• minimal to mild
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• subacute
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• nodular and discolored
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• centrilobular and coagulative in 28% of mice
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renal/urinary system
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• mice exhibit nephropathy unlike wild-type mice
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• 85% of mice exhibit bilateral glomerulopathy with global glomerular enlargement due to hypercellularity and increased matrix amount unlike in wild-type mice
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pale kidney
(
J:146743
)
homeostasis/metabolism
hematopoietic system
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• in 67% of spleens due to an expansion of red pulp
(J:146743)
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• CD44 high CD4+ T cells are increased in mice with hyperplasia or lymphomas
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• in spleens and lymph nodes
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• due to increased erythroid and myeloid cells
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dark spleen
(
J:146743
)
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• dark spleens
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behavior/neurological
growth/size/body
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• reduction in body size compared to wild-type mice at birth
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• the reduction in body size compared to wild-type mice observed at birth is less pronounced at 3 to 4 months of age
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• at P21
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weight loss
(
J:146176
)
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• at 8 to 10 months of age
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adipose tissue
immune system
myocarditis
(
J:146743
)
|
• in 57% of mice primarily involving the left ventricular free wall and septum
|
|
• CD44 high CD4+ T cells are increased in mice with hyperplasia or lymphomas
|
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• in spleens and lymph nodes
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• due to increased erythroid and myeloid cells
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dark spleen
(
J:146743
)
|
• dark spleens
|
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• 3 mice exhibit generalized lymphadenopathy characterized by non-specific, reactive lymphoid hyperplasia unlike in wild-type mice
|
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• most mice succumb to splenic, lymph node, and thymic lymphomas and lymphoid hyperplasias by week 58
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• subacute
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muscle
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• primarily involving the left ventricular free wall and septum
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skeleton
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• at 8 to 10 months of age
(J:146176)
• as early as 16 weeks of age
(J:146743)
|
neoplasm
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• lymphomas are first observed at 26 weeks of age
• most mice succumb to splenic, lymph node, and thymic lymphomas and lymphoid hyperplasias by week 58
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endocrine/exocrine glands
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• minimal to mild
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integument
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• as early as 16 weeks of age, mice have scruffy coats unlike wild-type mice
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