All Phenotypes Gabra6<tm2(cre)Wwis> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabra6^tm2(cre)Wwis/Gabra6^tm2(cre)Wwis	involves: 129P2/OlaHsd * C57BL/6	MGI:3718226
cn2	Gabra6^tm2(cre)Wwis/Gabra6⁺ Mfn2^tm1Dcc/Mfn2^tm3Dcc	involves: 129 * 129S4/SvJaeSor * Black Swiss	MGI:3779097
cn3	Slc12a5^tm2.1Tjj/Slc12a5^tm2.1Tjj Gabra6^tm2(cre)Wwis/Gabra6⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5315753
cn4	Slc12a5^tm2.1Tjj/Slc12a5^tm2.1Tjj Gabra6^tm2(cre)Wwis/Gabra6⁺ Tg(Pcp2-cre)2Mpin/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5315754

Allelic Composition	Gabra6^tm2(cre)Wwis/Gabra6^tm2(cre)Wwis
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra6^tm2(cre)Wwis mutation (2 available); any Gabra6 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:91624 )

Allelic Composition	Gabra6^tm2(cre)Wwis/Gabra6⁺ Mfn2^tm1Dcc/Mfn2^tm3Dcc
Genetic Background	involves: 129 * 129S4/SvJaeSor * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra6^tm2(cre)Wwis mutation (2 available); any Gabra6 mutation (38 available)
Mfn2^tm1Dcc mutation (0 available); any Mfn2 mutation (26 available)
Mfn2^tm3Dcc mutation (2 available); any Mfn2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:132329 )

• shows no defect in balance and coordination

• no anatomical abnormality in cerebella

Allelic Composition	Slc12a5^tm2.1Tjj/Slc12a5^tm2.1Tjj Gabra6^tm2(cre)Wwis/Gabra6⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra6^tm2(cre)Wwis mutation (2 available); any Gabra6 mutation (38 available)
Slc12a5^tm2.1Tjj mutation (0 available); any Slc12a5 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:181930 )

N	• mice exhibit normal cerebellar histology, synaptic morphology and synaptic function

abnormal cerebellar granule cell morphology ( J:181930 )

• resting membrane potential mediated by chloride ion extrusion in granule cells is disrupted compared to in wild-type mice

abnormal neuron morphology ( J:181930 )

• chloride ion concentration is increased 2-fold compared to in wild-type mice

abnormal action potential ( J:181930 )

• spontaneous Purkinje cell firing is irregular compared to in wild-type cells

behavior/neurological

behavior/neurological phenotype ( J:181930 )

N	• mice exhibit normal short-term, gain-decreased motor learning and dark, gain consolidation

abnormal learning/memory/conditioning ( J:181930 )

• mice exhibit impaired vestibuloocular reflex in the dark phase adjustment from day 4 (long-term memory consolidation) compared with wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:181930 )

• mice exhibit impairment in vestibuloocular reflex in the dark decrease learning and dark, gain consolidation compared with wild-type mice

• mice exhibit impaired vestibuloocular reflex in the dark phase adjustment from day 4 (long-term memory consolidation) compared with wild-type mice

abnormal motor learning ( J:181930 )

• mice exhibit impairment in vestibuloocular reflex in the dark decrease learning and dark, gain consolidation compared with wild-type mice

abnormal optokinetic reflex ( J:181930 )

• mice exhibit decreased gain in optokinetic reflex compared with wild-type mice

• mice exhibit a phase lag during optokinetic reflex compared with wild-type mice

abnormal vestibuloocular dark reflex ( J:181930 )

• mice exhibit a phase lag during vestibuloocular reflex in the dark compared with wild-type mice

• mice exhibit impairment in vestibuloocular reflex in the dark decrease learning compared with wild-type mice

abnormal vestibuloocular light reflex ( J:181930 )

• mice exhibit a phase lag during vestibuloocular reflex in the light compared with wild-type mice

nervous system

nervous system phenotype ( J:181930 )

N	• mice exhibit normal cerebellar histology, synaptic morphology and synaptic function

abnormal GABA-mediated receptor currents ( J:181930 )

• mice exhibit reduced GABA-induced chloride ion currents compared with wild-type mice that is not as severe as in Slc12a5^tm2.1Tjj/Slc12a5^tm2.1Tjj Tg(Pcp2-cre)2Mpin mice

hearing/vestibular/ear

abnormal vestibuloocular dark reflex ( J:181930 )

• mice exhibit a phase lag during vestibuloocular reflex in the dark compared with wild-type mice

• mice exhibit impairment in vestibuloocular reflex in the dark decrease learning compared with wild-type mice

abnormal vestibuloocular light reflex ( J:181930 )

• mice exhibit a phase lag during vestibuloocular reflex in the light compared with wild-type mice

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