Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm4.1Cgn mutation
(1 available);
any
Cd79a mutation
(22 available)
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hematopoietic system
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• B cell development is severely impaired
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immune system
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• B cell development is severely impaired
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm3Cgn mutation
(0 available);
any
Cd79a mutation
(22 available)
Cd79atm4.1Cgn mutation
(1 available);
any
Cd79a mutation
(22 available)
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immune system
N |
• following treatment with poly(I)/poly(C), B cell numbers are normal
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm4.1Cgn mutation
(1 available);
any
Cd79a mutation
(22 available)
Cd79atm4Cgn mutation
(0 available);
any
Cd79a mutation
(22 available)
Tg(Cr2-cre)3Cgn mutation
(2 available)
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hematopoietic system
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• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes
• B cell half life is about 3 - 6 days
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• B cell surface IgD levels are decreased about 100 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively
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• B cell surface IgM levels are decreased about 30 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively
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immune system
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• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes
• B cell half life is about 3 - 6 days
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• B cell surface IgD levels are decreased about 100 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively
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• B cell surface IgM levels are decreased about 30 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm4.1Cgn mutation
(1 available);
any
Cd79a mutation
(22 available)
Cd79atm4Cgn mutation
(0 available);
any
Cd79a mutation
(22 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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hematopoietic system
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• 2 weeks after p(I)p(C) injections an almost complete block in B cell development is seen
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• 2 weeks after p(I)p(C) injections two thirds of the B cells are lost from the spleen, blood, lymph nodes, liver, and lung
• mature follicular B cells are more affected than marginal zone B cells
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• in the spleen almost all immature spleen cells are missing
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immune system
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• 2 weeks after p(I)p(C) injections an almost complete block in B cell development is seen
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• 2 weeks after p(I)p(C) injections two thirds of the B cells are lost from the spleen, blood, lymph nodes, liver, and lung
• mature follicular B cells are more affected than marginal zone B cells
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• in the spleen almost all immature spleen cells are missing
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm4.1Cgn mutation
(1 available);
any
Cd79a mutation
(22 available)
Ightm1.2Rsky mutation
(0 available);
any
Igh mutation
(43 available)
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immune system
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• B cells do not develop past this stage
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hematopoietic system
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• B cells do not develop past this stage
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