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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbx1tm4(cre/Esr1*)Bld
targeted mutation 4, Antonio Baldini
MGI:3046795
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tbx1tm4(cre/Esr1*)Bld/Tbx1+ involves: 129P2/OlaHsd * 129S7/SvEvBrd MGI:3641321
cn2
 		Fgf8tm1.4Mrt/Fgf8+
Tbx1tm4(cre/Esr1*)Bld/Tbx1+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd MGI:3641318
cn3
 		Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tbx1tm4(cre/Esr1*)Bld/Tbx1+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd MGI:3641319
cn4
 		Fgf8tm1.3Mrt/Fgf8+
Tbx1tm4(cre/Esr1*)Bld/Tbx1+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd MGI:3641320


Genotype
MGI:3641321
ht1
Allelic
Composition		 Tbx1tm4(cre/Esr1*)Bld/Tbx1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx1tm4(cre/Esr1*)Bld mutation (1 available); any Tbx1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system




Genotype
MGI:3641318
cn2
Allelic
Composition		 Fgf8tm1.4Mrt/Fgf8+
Tbx1tm4(cre/Esr1*)Bld/Tbx1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1.4Mrt mutation (0 available); any Fgf8 mutation (25 available)
Tbx1tm4(cre/Esr1*)Bld mutation (1 available); any Tbx1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal aortic arch morphology ( J:110620 )
• defects are seen in 78% of fetuses at E18.5 when tamoxifen is administered at E8.5




Genotype
MGI:3641319
cn3
Allelic
Composition		 Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tbx1tm4(cre/Esr1*)Bld/Tbx1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1.3Mrt mutation (1 available); any Fgf8 mutation (25 available)
Fgf8tm1.4Mrt mutation (0 available); any Fgf8 mutation (25 available)
Tbx1tm4(cre/Esr1*)Bld mutation (1 available); any Tbx1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal aortic arch morphology ( J:110620 )
• defects are seen in 81, 88, and 89% of fetuses at E18.5 when tamoxifen is administered at E7.5, 8.5 or 9.5 respectively




Genotype
MGI:3641320
cn4
Allelic
Composition		 Fgf8tm1.3Mrt/Fgf8+
Tbx1tm4(cre/Esr1*)Bld/Tbx1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1.3Mrt mutation (1 available); any Fgf8 mutation (25 available)
Tbx1tm4(cre/Esr1*)Bld mutation (1 available); any Tbx1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal aortic arch morphology ( J:110620 )
• defects are seen in 52, 32, and 63% of fetuses at E18.5 when tamoxifen is administered at E7.5, 8.5 or 9.5 respectively




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory