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Tbx1tm4(cre/Esr1*)Bld
Targeted Allele Detail
Summary
Symbol: Tbx1tm4(cre/Esr1*)Bld
Name: T-box 1; targeted mutation 4, Antonio Baldini
MGI ID: MGI:3046795
Synonyms: Tbx1mcm, Tbx1tm4(cre/Esr1)Bld
Gene: Tbx1  Location: Chr16:18399729-18409412 bp, - strand  Genetic Position: Chr16, Syntenic
Alliance: Tbx1tm4(cre/Esr1*)Bld page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91013
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tbx1tm4(cre/Esr1*)Bld expression driven by 1 gene
 
Mutation detailsAn IRES and MerCreMer fusion gene were inserted into exon 5 via homologous recombination. This is the same insertion site as in Tbx1tm1Bld. This results in tamoxifen-inducible cre expression under the control of the endogenous Tbx1 promoter. (J:91013)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tbx1 (mouse)
Summary of all recombinase alleles driven by Tbx1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:  35 strains or lines available
References
Original:  J:91013 Xu H, et al., Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development. 2004 Jul;131(13):3217-27
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory