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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrp5tm1Jfh
targeted mutation 1, J Fred Hess
MGI:3046356
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lrp5tm1Jfh/Lrp5tm1Jfh involves: 129S5/SvEvBrd * C57BL/6 MGI:3046419
cx2
 		Lrp5tm1Jfh/Lrp5tm1Jfh
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg 		involves: 129S5/SvEvBrd * C57BL/6 MGI:3046420
cx3
 		Lrp5tm1Jfh/Lrp5tm1Jfh
Lrp6Gt(Ex187)Byg/Lrp6+ 		involves: 129S5/SvEvBrd * C57BL/6 MGI:3046421
cx4
 		Lrp5tm1Jfh/Lrp5+
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg 		involves: 129S5/SvEvBrd * C57BL/6 MGI:3046422
cx5
 		Lrp5tm1Jfh/Lrp5+
Lrp6Gt(Ex187)Byg/Lrp6+ 		involves: 129S5/SvEvBrd * C57BL/6 MGI:3046423


Genotype
MGI:3046419
hm1
Allelic
Composition		 Lrp5tm1Jfh/Lrp5tm1Jfh
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1Jfh mutation (0 available); any Lrp5 mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal phalanx morphology ( J:91055 )
• loss of ossification in the mid phalanx at 8.5 is reported
• while this is the only specific phenotype reported for this allele, it is implied that this allele is similar to those reported earlier

skeleton
abnormal phalanx morphology ( J:91055 )
• loss of ossification in the mid phalanx at 8.5 is reported
• while this is the only specific phenotype reported for this allele, it is implied that this allele is similar to those reported earlier




Genotype
MGI:3046420
cx2
Allelic
Composition		 Lrp5tm1Jfh/Lrp5tm1Jfh
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1Jfh mutation (0 available); any Lrp5 mutation (81 available)
Lrp6Gt(Ex187)Byg mutation (1 available); any Lrp6 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:91055 )
• development arrested prior to E10.5
• homozygotes die by E18.5

embryo
abnormal developmental patterning ( J:91055 )
• embryonic development normal until gastrulation
• visibly smaller and abnormal by E7.5
absent endoderm ( J:91055 )
• absence of definitive endoderm
absent allantois ( J:91055 )
• no visible allantois




Genotype
MGI:3046421
cx3
Allelic
Composition		 Lrp5tm1Jfh/Lrp5tm1Jfh
Lrp6Gt(Ex187)Byg/Lrp6+
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1Jfh mutation (0 available); any Lrp5 mutation (81 available)
Lrp6Gt(Ex187)Byg mutation (1 available); any Lrp6 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:91055 )
• reduced viability with deaths occurring after birth

growth/size/body
decreased body size ( J:91055 )
• survivors are small as adults
decreased fetal size ( J:91055 )
• smaller size at E18.5

limbs/digits/tail
absent carpal bone ( J:91055 )
• missing carpal bones
oligodactyly ( J:91055 )
• loss of one or two digits on the forelimb
• only 1 or 2 digits present in the hind limb
absent metacarpal bones ( J:91055 )
• missing metacarpals

skeleton
absent carpal bone ( J:91055 )
• missing carpal bones
absent metacarpal bones ( J:91055 )
• missing metacarpals




Genotype
MGI:3046422
cx4
Allelic
Composition		 Lrp5tm1Jfh/Lrp5+
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1Jfh mutation (0 available); any Lrp5 mutation (81 available)
Lrp6Gt(Ex187)Byg mutation (1 available); any Lrp6 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:91055 )
• development arrested prior to E10.5
• mice die by E18

embryo
abnormal developmental patterning ( J:91055 )
• embryonic development normal until gastrulation
• posterior portion of the embryo sometimes remains undifferentiated
abnormal primitive streak formation ( J:91055 )
• failure of some nascent mesoderm to migrate properly from the primitive streak
absent somites ( J:91055 )
• no visible somites
abnormal amnion morphology ( J:91055 )
• by E7.5 an abnormal accumulation of cells protrudes into the amniotic cavity

nervous system
increased forebrain size ( J:91055 )
• greatly enlarged by E7.5
• posterior regions of the brain not affected




Genotype
MGI:3046423
cx5
Allelic
Composition		 Lrp5tm1Jfh/Lrp5+
Lrp6Gt(Ex187)Byg/Lrp6+
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1Jfh mutation (0 available); any Lrp5 mutation (81 available)
Lrp6Gt(Ex187)Byg mutation (1 available); any Lrp6 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
forelimb oligodactyly ( J:91055 )
• postaxial digit loss
• typically 1 digit lost on right forelimb

skeleton
abnormal bone ossification ( J:91055 )
• loss of multiple ossification centers




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory