All Phenotypes Lrp5<tm1Jfh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lrp5^tm1Jfh
targeted mutation 1, J Fred Hess
MGI:3046356

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrp5^tm1Jfh/Lrp5^tm1Jfh	involves: 129S5/SvEvBrd * C57BL/6	MGI:3046419
cx2	Lrp5^tm1Jfh/Lrp5^tm1Jfh Lrp6^Gt(Ex187)Byg/Lrp6^Gt(Ex187)Byg	involves: 129S5/SvEvBrd * C57BL/6	MGI:3046420
cx3	Lrp5^tm1Jfh/Lrp5^tm1Jfh Lrp6^Gt(Ex187)Byg/Lrp6⁺	involves: 129S5/SvEvBrd * C57BL/6	MGI:3046421
cx4	Lrp5^tm1Jfh/Lrp5⁺ Lrp6^Gt(Ex187)Byg/Lrp6^Gt(Ex187)Byg	involves: 129S5/SvEvBrd * C57BL/6	MGI:3046422
cx5	Lrp5^tm1Jfh/Lrp5⁺ Lrp6^Gt(Ex187)Byg/Lrp6⁺	involves: 129S5/SvEvBrd * C57BL/6	MGI:3046423

Allelic Composition	Lrp5^tm1Jfh/Lrp5^tm1Jfh
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^tm1Jfh mutation (0 available); any Lrp5 mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal phalanx morphology ( J:91055 )

• loss of ossification in the mid phalanx at 8.5 is reported

• while this is the only specific phenotype reported for this allele, it is implied that this allele is similar to those reported earlier

skeleton

abnormal phalanx morphology ( J:91055 )

• loss of ossification in the mid phalanx at 8.5 is reported

• while this is the only specific phenotype reported for this allele, it is implied that this allele is similar to those reported earlier

Allelic Composition	Lrp5^tm1Jfh/Lrp5^tm1Jfh Lrp6^Gt(Ex187)Byg/Lrp6^Gt(Ex187)Byg
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^tm1Jfh mutation (0 available); any Lrp5 mutation (83 available)
Lrp6^Gt(Ex187)Byg mutation (1 available); any Lrp6 mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:91055 )

• development arrested prior to E10.5

• homozygotes die by E18.5

embryo

abnormal developmental patterning ( J:91055 )

• embryonic development normal until gastrulation

• visibly smaller and abnormal by E7.5

abnormal germ layer development ( J:91055 )

abnormal mesoderm development ( J:91055 )

absent endoderm ( J:91055 )

• absence of definitive endoderm

absent allantois ( J:91055 )

• no visible allantois

absent amnion ( J:91055 )

Allelic Composition	Lrp5^tm1Jfh/Lrp5^tm1Jfh Lrp6^Gt(Ex187)Byg/Lrp6⁺
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:91055 )

• reduced viability with deaths occurring after birth

growth/size/body

decreased body size ( J:91055 )

• survivors are small as adults

decreased fetal size ( J:91055 )

• smaller size at E18.5

limbs/digits/tail

absent carpal bone ( J:91055 )

• missing carpal bones

oligodactyly ( J:91055 )

• loss of one or two digits on the forelimb

• only 1 or 2 digits present in the hind limb

absent fibula ( J:91055 )

absent metacarpal bones ( J:91055 )

• missing metacarpals

skeleton

absent carpal bone ( J:91055 )

• missing carpal bones

absent fibula ( J:91055 )

absent metacarpal bones ( J:91055 )

• missing metacarpals

Allelic Composition	Lrp5^tm1Jfh/Lrp5⁺ Lrp6^Gt(Ex187)Byg/Lrp6^Gt(Ex187)Byg
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:91055 )

• development arrested prior to E10.5

• mice die by E18

embryo

abnormal developmental patterning ( J:91055 )

• embryonic development normal until gastrulation

• posterior portion of the embryo sometimes remains undifferentiated

abnormal primitive streak formation ( J:91055 )

• failure of some nascent mesoderm to migrate properly from the primitive streak

absent somites ( J:91055 )

• no visible somites

abnormal extraembryonic tissue morphology ( J:91055 )

abnormal amnion morphology ( J:91055 )

• by E7.5 an abnormal accumulation of cells protrudes into the amniotic cavity

nervous system

increased forebrain size ( J:91055 )

• greatly enlarged by E7.5

• posterior regions of the brain not affected

Allelic Composition	Lrp5^tm1Jfh/Lrp5⁺ Lrp6^Gt(Ex187)Byg/Lrp6⁺
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

forelimb oligodactyly ( J:91055 )

• postaxial digit loss

• typically 1 digit lost on right forelimb

skeleton

abnormal bone ossification ( J:91055 )

• loss of multiple ossification centers

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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