Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm2(RHO/GFP)Jhw mutation
(0 available);
any
Rho mutation
(48 available)
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vision/eye
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• retinas begin to degenerate within a 3-5 months after birth
• retinal degeneration is not as severe as in Rhotm3Jhw homozygote
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm2(RHO/GFP)Jhw mutation
(0 available);
any
Rho mutation
(48 available)
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vision/eye
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• the outer and inner segment boundaries are difficult to distinguish at 3, 6, and 8 weeks
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• at 2 weeks, nascent rod outer segments exhibit non-uniform clumps unlike in wild-type mice
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• whether light/dark reared or dark-only reared
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nervous system
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• the outer and inner segment boundaries are difficult to distinguish at 3, 6, and 8 weeks
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• at 2 weeks, nascent rod outer segments exhibit non-uniform clumps unlike in wild-type mice
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Allelic Composition |
Rhotm2(RHO/GFP)Jhw/Rho+
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Genetic Background |
either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc * FVB) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm2(RHO/GFP)Jhw mutation
(0 available);
any
Rho mutation
(48 available)
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vision/eye
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• mild retinal degeneration is seen with the number of nuclei in the outer nuclear layer being reduced to about 50% wild-type
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Allelic Composition |
Pde6brd1/Pde6brd1 Rhotm2(RHO/GFP)Jhw/Rho+
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Genetic Background |
either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc * FVB) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde6brd1 mutation
(41 available);
any
Pde6b mutation
(119 available)
Rhotm2(RHO/GFP)Jhw mutation
(0 available);
any
Rho mutation
(48 available)
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vision/eye
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• retinas begin to degenerate within 9 days after birth
• GFP expression can clearly be seen as the retinas degenerate
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