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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lect2tm1Ymg
targeted mutation 1, Satoshi Yamagoe
MGI:3045975
Summary 3 genotypes


Genotype
MGI:3046057
hm1
Allelic
Composition		 Lect2tm1Ymg/Lect2tm1Ymg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lect2tm1Ymg mutation (0 available); any Lect2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased T cell number ( J:90961 )
• the percent of hepatic CD3int and CD4+ NK1.1+ T cells is significantly higher compared to wild-type mice
• the proportion of CD4+ among the CD3int NK1.1+ T cells is also increased
abnormal leukocyte physiology ( J:90961 )
• hepatic but not splenic mononuclear cells are significantly more cytotoxic to syngeneic thymocytes and YAC-1 cells
increased T cell apoptosis ( J:90961 )
• 3 hours after Con A injection CD3int NK1.1+ T cells show increased apoptosis

immune system
increased T cell number ( J:90961 )
• the percent of hepatic CD3int and CD4+ NK1.1+ T cells is significantly higher compared to wild-type mice
• the proportion of CD4+ among the CD3int NK1.1+ T cells is also increased
abnormal leukocyte physiology ( J:90961 )
• hepatic but not splenic mononuclear cells are significantly more cytotoxic to syngeneic thymocytes and YAC-1 cells
increased T cell apoptosis ( J:90961 )
• 3 hours after Con A injection CD3int NK1.1+ T cells show increased apoptosis
abnormal cytokine secretion ( J:90961 )
• in response to alpha-GalCer mutant mice produce significantly more IL-4 and slightly more IFN-gamma
• in response to Con A injection mutant mice produce significantly more IL-4
liver inflammation ( J:90961 )
• 5 hours after Con A injection mutant livers show focal degenerative change and clusters of apoptotic cells

liver/biliary system
liver inflammation ( J:90961 )
• 5 hours after Con A injection mutant livers show focal degenerative change and clusters of apoptotic cells

cellular
increased T cell apoptosis ( J:90961 )
• 3 hours after Con A injection CD3int NK1.1+ T cells show increased apoptosis




Genotype
MGI:5430589
cn2
Allelic
Composition		 Apctm2.1Cip/Apctm2.1Cip
Lect2tm1Ymg/Lect2tm1Ymg
Tg(Ttr-cre/Esr1*)1Vco/0
Genetic
Background		 B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2.1Cip mutation (2 available); any Apc mutation (154 available)
Lect2tm1Ymg mutation (0 available); any Lect2 mutation (12 available)
Tg(Ttr-cre/Esr1*)1Vco mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:184496 )
• tamoxifen treated mutants exhibit a decrease in survival rate

liver/biliary system
increased hepatocyte apoptosis ( J:184496 )
• increase in liver apoptosis in tamoxifen treated mutants
liver inflammation ( J:184496 )
• liver inflammation is increased in tamoxifen treated mutants compared to single Apc mutants
abnormal liver morphology ( J:184496 )
• livers of tamoxifen treated mutants exhibit a flaccid and loose texture compared to livers from single Apc homozygotes
• mutants injected with tamoxifen exhibit significantly higher total numbers of nonparenchymal cells (NPCs) in the liver
hepatic necrosis ( J:184496 )
• in tamoxifen treated mutants

immune system
increased NK T cell number ( J:184496 )
• number of iNKT cells in the liver is increased in tamoxifen-treated double mutants compared to single Apc mutants
abnormal neutrophil physiology ( J:184496 )
• liver infiltrating immune cells of tamoxifen treated mutants have an increase in neutrophils compared to infiltrating immune cells in single Apc mutants
abnormal NK T cell physiology ( J:184496 )
• invariant NKTs (iNKTs) are more activated in tamoxifen treated double mutant livers than in single Apc mutant livers
abnormal chemokine level ( J:184496 )
• chemokines in the liver of tamoxifen treated mutants, such as Cxcl1, Cxcl12, and Cxcl12 are induced to higher levels in double mutants than in single Apc mutants
decreased interferon-gamma secretion ( J:184496 )
• CD4- iNKTs from tamoxifen treated mutants produce less IFN-gamma than CD4- iNKTs of single Apc mutants
increased interleukin-4 secretion ( J:184496 )
• CD4- iNKTs from tamoxifen treated mutants produce more IL-4 than CD4- iNKTs of single Apc mutants
liver inflammation ( J:184496 )
• liver inflammation is increased in tamoxifen treated mutants compared to single Apc mutants

homeostasis/metabolism
abnormal circulating enzyme level ( J:184496 )
• serum transaminase levels are higher in tamoxifen treated mutants than in single Apc homozygotes
abnormal chemokine level ( J:184496 )
• chemokines in the liver of tamoxifen treated mutants, such as Cxcl1, Cxcl12, and Cxcl12 are induced to higher levels in double mutants than in single Apc mutants

hematopoietic system
increased NK T cell number ( J:184496 )
• number of iNKT cells in the liver is increased in tamoxifen-treated double mutants compared to single Apc mutants
abnormal neutrophil physiology ( J:184496 )
• liver infiltrating immune cells of tamoxifen treated mutants have an increase in neutrophils compared to infiltrating immune cells in single Apc mutants
abnormal NK T cell physiology ( J:184496 )
• invariant NKTs (iNKTs) are more activated in tamoxifen treated double mutant livers than in single Apc mutant livers

cellular
increased hepatocyte apoptosis ( J:184496 )
• increase in liver apoptosis in tamoxifen treated mutants
hepatic necrosis ( J:184496 )
• in tamoxifen treated mutants




Genotype
MGI:5430590
cx3
Allelic
Composition		 Lect2tm1Ymg/Lect2tm1Ymg
Tg(Pklr-Myc)73Ak/0
Genetic
Background		 B6.Cg-Lect2tm1Ymg Tg(Pklr-Myc)73Ak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lect2tm1Ymg mutation (0 available); any Lect2 mutation (12 available)
Tg(Pklr-Myc)73Ak mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased malignant tumor incidence ( J:184496 )
• tumors have higher grades of malignancy and are less differentiated than those of single Tg(Pklr-Myc)73Ak mice
increased hepatocellular carcinoma incidence ( J:184496 )
• mutants develop hepatocellular carcinoma
• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice
• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice
• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

liver/biliary system
increased hepatocellular carcinoma incidence ( J:184496 )
• mutants develop hepatocellular carcinoma
• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice
• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice
• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
 J:184496




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04/16/2024
MGI 6.23 		The Jackson Laboratory