Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Teftm1Schb mutation
(2 available);
any
Tef mutation
(13 available)
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behavior/neurological
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• spontaneous high-voltage spikes and absence-like seizures
• no generalized tonic-clonic epilepsies
• less frequent than in triple knockout mice (Dbptm1Schb/tm1Schb, Hlftm1Schb/tm1Schb, Teftm1Schb/tm1Schb)
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nervous system
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• spontaneous high-voltage spikes and absence-like seizures
• no generalized tonic-clonic epilepsies
• less frequent than in triple knockout mice (Dbptm1Schb/tm1Schb, Hlftm1Schb/tm1Schb, Teftm1Schb/tm1Schb)
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behavior/neurological
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• several seizure-like activities are observed in mutants, however they never develop into generalized epilepsies
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• several absence-like seizures without any sign of EEG hypoactivity are seen
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nervous system
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• several seizure-like activities are observed in mutants, however they never develop into generalized epilepsies
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• several absence-like seizures without any sign of EEG hypoactivity are seen
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• analysis of sleep EEG of a 12-hour light period shows an increase in slow-wave delta activity and a decrease in theta activity, however this is much less pronounced than in triple homozygous mutants
• activity in all frequency bins greater than 15 Hz (the beta frequency range) is increased in waking mutants
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cardiovascular system
liver/biliary system
mortality/aging
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• 50% of mice die within the first 2 months of age due to lethal seizures
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behavior/neurological
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• mice are hypersensitive to xenobiotic compounds including pentobarbital
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• a circadian trend of seizure occurance is observed, with 4-times more seizures occuring during early light period hours (major sleep period) than during early dark period hours (major active period)
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• observed in some mice; audiogenic seizures account for about 25% of all deceased mice
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• spontaneous tonic-clonic seizures that occur predominantly within slow-wave sleep during the first 2 min after transition to sleep
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• observe a few absence-like seizures without any sign of EEG hypoactivity
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nervous system
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• a circadian trend of seizure occurance is observed, with 4-times more seizures occuring during early light period hours (major sleep period) than during early dark period hours (major active period)
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• observed in some mice; audiogenic seizures account for about 25% of all deceased mice
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• spontaneous tonic-clonic seizures that occur predominantly within slow-wave sleep during the first 2 min after transition to sleep
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• observe a few absence-like seizures without any sign of EEG hypoactivity
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• reduction in levels of serotonin and dopamine and increase in levels of histamine in the brain
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• analysis of sleep EEG of a 12-hour light period shows a significant increase in slow-wave delta activity and a significant decrease in theta activity
• activity in all frequency bins greater than 15 Hz (the beta frequency range) is significantly increased during all vigilance states
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homeostasis/metabolism
growth/size/body
mortality/aging
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• succumb to sudden death
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mortality/aging
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• succumb to sudden death
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Analysis Tools