Hlf^tm1Schb
Targeted Allele Detail

Summary

• Symbol: Hlf^tm1Schb
• Name: hepatic leukemia factor; targeted mutation 1, Ueli Schibler
• MGI ID: MGI:3045480
• Synonyms: Hlf-, PAR bZIP^-
• Gene: Hlf Location: Chr11:90227362-90281721 bp, - strand Genetic Position: Chr11, 55.03 cM
• Alliance: Hlf^tm1Schb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90854
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ and PGK-neo replaced exon 2, which encodes the transactivation domain. RT-PCR did not detect transcripts in mutant mice. (J:90854)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hlf Mutation: 15 strains or lines available

References

• Original: J:90854 Gachon F, et al., The loss of circadian PAR bZip transcription factors results in epilepsy. Genes Dev. 2004 Jun 15;18(12):1397-412
• All: 12 reference(s)