Dbp^tm1Schb
Targeted Allele Detail

Summary

• Symbol: Dbp^tm1Schb
• Name: D site albumin promoter binding protein; targeted mutation 1, Ueli Schibler
• MGI ID: MGI:2183196
• Synonyms: Dbp^null, PAR bZIP^-, replacement KO
• Gene: Dbp Location: Chr7:45354658-45359579 bp, + strand Genetic Position: Chr7, 29.45 cM
• Alliance: Dbp^tm1Schb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44434
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region, consisting of sequence from exons 1 through 4, was replaced with a cassette containing lacZ and neo. Neither transcript nor protein was detected in homozygous mutant mice via RNA protection assays and immunoblot analysis of hepatic cells. (J:44434)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dbp Mutation: 21 strains or lines available

References

• Original: J:44434 Lopez-Molina L, et al., The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior. EMBO J. 1997 Nov 17;16(22):6762-71
• All: 14 reference(s)