|
Allele Symbol Allele Name Allele ID |
Dbptm1Schb targeted mutation 1, Ueli Schibler MGI:2183196 |
||||||||||||||||||||
| Summary |
4 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• generate about 40% fewer wheel revolutions and show less spontaneous activity under light/dark conditions
• overall decrease in activity is mostly the result of decreased activity during the dark phase
|
|
• moderately but significantly shorter compared to controls under dark/dark conditions
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• increased liver mass
|
|
• 50% of mice die within the first 2 months of age due to lethal seizures
|
|
• mice are hypersensitive to xenobiotic compounds including pentobarbital
|
|
• a circadian trend of seizure occurance is observed, with 4-times more seizures occuring during early light period hours (major sleep period) than during early dark period hours (major active period)
|
|
• observed in some mice; audiogenic seizures account for about 25% of all deceased mice
|
|
• spontaneous tonic-clonic seizures that occur predominantly within slow-wave sleep during the first 2 min after transition to sleep
|
|
• observe a few absence-like seizures without any sign of EEG hypoactivity
|
|
• a circadian trend of seizure occurance is observed, with 4-times more seizures occuring during early light period hours (major sleep period) than during early dark period hours (major active period)
|
|
• observed in some mice; audiogenic seizures account for about 25% of all deceased mice
|
|
• spontaneous tonic-clonic seizures that occur predominantly within slow-wave sleep during the first 2 min after transition to sleep
|
|
• observe a few absence-like seizures without any sign of EEG hypoactivity
|
|
• reduction in levels of serotonin and dopamine and increase in levels of histamine in the brain
|
|
• analysis of sleep EEG of a 12-hour light period shows a significant increase in slow-wave delta activity and a significant decrease in theta activity
• activity in all frequency bins greater than 15 Hz (the beta frequency range) is significantly increased during all vigilance states
|
|
• increased plasma levels of alanine aminotransferase
|
|
• reduction in levels of dopamine in the brain
|
|
• reduction in the levels of serotonin in the brain
|
|
• mice are hypersensitive to xenobiotic compounds including pentobarbital, mitoxantrone and cyclophosphamide
|
|
• increased liver mass
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• several seizure-like activities are observed in mutants, however they never develop into generalized epilepsies
|
|
• several absence-like seizures without any sign of EEG hypoactivity are seen
|
|
• several seizure-like activities are observed in mutants, however they never develop into generalized epilepsies
|
|
• several absence-like seizures without any sign of EEG hypoactivity are seen
|
|
• analysis of sleep EEG of a 12-hour light period shows an increase in slow-wave delta activity and a decrease in theta activity, however this is much less pronounced than in triple homozygous mutants
• activity in all frequency bins greater than 15 Hz (the beta frequency range) is increased in waking mutants
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/07/2024 MGI 6.23 |
|
|
|
||
Analysis Tools