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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slamf1tm1Cpt
targeted mutation 1, Cox Terhorst
MGI:3044919
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slamf1tm1Cpt/Slamf1tm1Cpt B6.129S4-Slamf1tm1Cpt MGI:3044983
hm2
 		Slamf1tm1Cpt/Slamf1tm1Cpt C.129S4-Slamf1tm1Cpt MGI:3044986
cx3
 		Slamf1tm1Cpt/Slamf1tm1Cpt
Tg(DO11.10)10Dlo/Tg(DO11.10)10Dlo 		involves: BALB/c * C3H * C57BL/6 MGI:3044988


Genotype
MGI:3044983
hm1
Allelic
Composition		 Slamf1tm1Cpt/Slamf1tm1Cpt
Genetic
Background		 B6.129S4-Slamf1tm1Cpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slamf1tm1Cpt mutation (0 available); any Slamf1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:90484 )
• lipopolysaccharide and/or Infg stimulated macrophages from homozygotes produce less Tnf, Il12, and NO compared to wild-type littermates
• Tnf secretion was normal when macrophages were stimulated with CpG or peptidoglycan
abnormal cytokine secretion ( J:90484 )
• CD8+ and to a lesser extent CD4+ T cells produce more IFN-gamma following anti-CD3 and anti-CD28 stimulation
• CD4+ T cells produce less IL-4 following treatment with anti-CD3 +/- anti-CD28
increased susceptibility to parasitic infection ( J:90484 )
• homozygous mutants have an impaired ability to clear infections of L. major on a C57BL/6 background but not on a BALB/c background

hematopoietic system
abnormal macrophage physiology ( J:90484 )
• lipopolysaccharide and/or Infg stimulated macrophages from homozygotes produce less Tnf, Il12, and NO compared to wild-type littermates
• Tnf secretion was normal when macrophages were stimulated with CpG or peptidoglycan




Genotype
MGI:3044986
hm2
Allelic
Composition		 Slamf1tm1Cpt/Slamf1tm1Cpt
Genetic
Background		 C.129S4-Slamf1tm1Cpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slamf1tm1Cpt mutation (0 available); any Slamf1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:90484 )
• lipopolysaccharide and/or Infg stimulated macrophages from homozygotes produce less Tnf, Il12, and NO compared to wild-type littermates
abnormal cytokine secretion ( J:90484 )
• CD4+ T cells produce less IL-4 following treatment with anti-CD3 +/- anti-CD28
• CD4+ T cells produce slightly more IFN-gamma following treatment with anti-CD3 +/- anti-CD28

hematopoietic system
abnormal macrophage physiology ( J:90484 )
• lipopolysaccharide and/or Infg stimulated macrophages from homozygotes produce less Tnf, Il12, and NO compared to wild-type littermates




Genotype
MGI:3044988
cx3
Allelic
Composition		 Slamf1tm1Cpt/Slamf1tm1Cpt
Tg(DO11.10)10Dlo/Tg(DO11.10)10Dlo
Genetic
Background		 involves: BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slamf1tm1Cpt mutation (0 available); any Slamf1 mutation (24 available)
Tg(DO11.10)10Dlo mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:90484 )
• CD4+ T cells produce less IL-4 following treatment with OVA peptide-pulsed antigen presenting cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory