Slamf1^tm1Cpt
Targeted Allele Detail

Summary

• Symbol: Slamf1^tm1Cpt
• Name: signaling lymphocytic activation molecule family member 1; targeted mutation 1, Cox Terhorst
• MGI ID: MGI:3044919
• Synonyms: SLAM^-
• Gene: Slamf1 Location: Chr1:171594700-171628752 bp, + strand Genetic Position: Chr1, 79.54 cM
• Alliance: Slamf1^tm1Cpt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90484
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3, IgV and IgC, which encode the complete ectodomain of the protein, were replaced with a neo cassette. Southern blot confirmed recombination in mutant mouse tail DNA and RT-PCR indicated no transcript in thymus or spleen of mutant mice. Flow cytometry demonstrated no surface expression in mutant thymocytes. (J:90484)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slamf1 Mutation: 24 strains or lines available

References

• Original: J:90484 Wang N, et al., The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions. J Exp Med. 2004 May 3;199(9):1255-64
• All: 14 reference(s)