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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hc1
sufficient
MGI:3044820
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hc1/Hc1 Not Specified MGI:3718225
cx2
 		Hc1/Hc1
Tg(APPswe,PSEN1dE9)85Dbo/0 		D2.Cg-Tg(APPswe,PSEN1dE9)85Dbo MGI:5702670
cx3
 		Hc1/?
Tg(TcrbBL17)1Lmor/0 		involves: DBA/1J * SWR/J MGI:3790655


Genotype
MGI:3718225
hm1
Allelic
Composition		 Hc1/Hc1
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hc1 mutation (7 available); any Hc mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:5016 )
• This is equivalent to the wild-type allele.




Genotype
MGI:5702670
cx2
Allelic
Composition		 Hc1/Hc1
Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic
Background		 D2.Cg-Tg(APPswe,PSEN1dE9)85Dbo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hc1 mutation (7 available); any Hc mutation (123 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
amyloid beta deposits ( J:227541 )
• Background Sensitivity: the complement pathway does not impact plaque deposition in the cortex, the number of plaques is the same as that in transgene carriers with the DBA/2J allele of Hc

behavior/neurological
convulsive seizures ( J:227541 )
• Background Sensitivity: despite the presence of functional hemolytic complement these mice have the same rate of lethal seizures as transgenics with the non-functional DBA/2J allele

mortality/aging

nervous system
nervous system phenotype ( J:227541 )
N
• no significant differences are found in cortical neuron number in complement deficient versus functional transgene carriers
convulsive seizures ( J:227541 )
• Background Sensitivity: despite the presence of functional hemolytic complement these mice have the same rate of lethal seizures as transgenics with the non-functional DBA/2J allele
amyloid beta deposits ( J:227541 )
• Background Sensitivity: the complement pathway does not impact plaque deposition in the cortex, the number of plaques is the same as that in transgene carriers with the DBA/2J allele of Hc




Genotype
MGI:3790655
cx3
Allelic
Composition		 Hc1/?
Tg(TcrbBL17)1Lmor/0
Genetic
Background		 involves: DBA/1J * SWR/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hc1 mutation (7 available); any Hc mutation (123 available)
Tg(TcrbBL17)1Lmor mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to induced arthritis ( J:134111 )
• susceptibility to collagen-induced arthritis
• trangenic animals affected with collagen-induced arthritis all carried at least one functional Hc allele

skeleton
increased susceptibility to induced arthritis ( J:134111 )
• susceptibility to collagen-induced arthritis
• trangenic animals affected with collagen-induced arthritis all carried at least one functional Hc allele




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory