Phenotypes associated with this allele
Allelic
Composition |
Hc1/Hc1
|
|
Genetic
Background |
Not Specified |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hc1 mutation
(7 available);
any
Hc mutation
(127 available)
|
|
|
normal phenotype
|
|
• This is equivalent to the wild-type allele.
|
homeostasis/metabolism
behavior/neurological
|
|
• Background Sensitivity: despite the presence of functional hemolytic complement these mice have the same rate of lethal seizures as transgenics with the non-functional DBA/2J allele
|
mortality/aging
nervous system
|
N |
• no significant differences are found in cortical neuron number in complement deficient versus functional transgene carriers
|
|
|
• Background Sensitivity: despite the presence of functional hemolytic complement these mice have the same rate of lethal seizures as transgenics with the non-functional DBA/2J allele
|
|
|
• Background Sensitivity: the complement pathway does not impact plaque deposition in the cortex, the number of plaques is the same as that in transgene carriers with the DBA/2J allele of Hc
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hc1 mutation
(7 available);
any
Hc mutation
(127 available)
Tg(TcrbBL17)1Lmor mutation
(0 available)
|
|
|
immune system
|
|
• susceptibility to collagen-induced arthritis
• trangenic animals affected with collagen-induced arthritis all carried at least one functional Hc allele
|
skeleton
|
|
• susceptibility to collagen-induced arthritis
• trangenic animals affected with collagen-induced arthritis all carried at least one functional Hc allele
|
Analysis Tools
