Hc¹
Allele Detail

Summary

• Symbol: Hc¹
• Name: hemolytic complement; sufficient
• MGI ID: MGI:3044820
• Synonyms: C5-s, C5-suf, C5 sufficient
• Gene: Hc Location: Chr2:34873343-34951450 bp, - strand Genetic Position: Chr2, 23.22 cM, cytoband cen-C1
• Alliance: Hc¹ page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Not Applicable
• Mutation: Not Applicable
• Mutation details: This allele does not contain the 2 base "TA" deletion found in the Hc⁰ allele and is found in the following mouse strains BALB/cJ, C57BL/6J, DBA/1J, and B10.D2/nSnJ. This is equivalent to the wild-type allele. (J:23983, J:298192)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Hc Mutation: 123 strains or lines available

Notes

Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The C3H/HeJ allele does not have the 2 bp deletion and is associated with resistance to allergen-induced bronchial hyperresponsiveness. (J:108211)

References

• Original: J:5016 Nilsson UR, et al., Deficiency of the fifth component of complement in mice with an inherited complement defect. J Exp Med. 1967 Jan 1;125(1):1-16
• All: 38 reference(s)