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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcf7l1tm1Efu
targeted mutation 1, Elaine Fuchs
MGI:3044615
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tcf7l1tm1Efu/Tcf7l1tm1Efu
Tg(Vil1-cre/ERT2)23Syr/0 		involves: 129 * C57BL/6 * DBA/2 MGI:5430370
cn2
 		Tcf7tm1Cle/Tcf7tm1Cle
Tcf7l1tm1Efu/Tcf7l1tm1Efu
Tg(Vil1-cre/ERT2)23Syr/0 		involves: 129 * C57BL/6 * DBA/2 MGI:5430371
cn3
 		Tcf7tm1Cle/Tcf7tm1Cle
Tcf7l1tm1Efu/Tcf7l1tm1Efu
Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle
Tg(Vil1-cre/ERT2)23Syr/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5430369
cn4
 		Hesx1tm1(cre)Jpmb/Hesx1+
Tcf7l1tm1Efu/Tcf7l1tm2Efu 		involves: 129S/SvEv * C57BL/6 MGI:5314534


Genotype
MGI:5430370
cn1
Allelic
Composition		 Tcf7l1tm1Efu/Tcf7l1tm1Efu
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l1tm1Efu mutation (0 available); any Tcf7l1 mutation (83 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:185753 )
N
• tamoxifen-treated mice exhibit normal adult intestinal homeostasis




Genotype
MGI:5430371
cn2
Allelic
Composition		 Tcf7tm1Cle/Tcf7tm1Cle
Tcf7l1tm1Efu/Tcf7l1tm1Efu
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l1tm1Efu mutation (0 available); any Tcf7l1 mutation (83 available)
Tcf7tm1Cle mutation (0 available); any Tcf7 mutation (29 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:185753 )
N
• tamoxifen-treated mice exhibit normal adult intestinal homeostasis




Genotype
MGI:5430369
cn3
Allelic
Composition		 Tcf7tm1Cle/Tcf7tm1Cle
Tcf7l1tm1Efu/Tcf7l1tm1Efu
Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l1tm1Efu mutation (0 available); any Tcf7l1 mutation (83 available)
Tcf7l2tm2.1Cle mutation (0 available); any Tcf7l2 mutation (58 available)
Tcf7tm1Cle mutation (0 available); any Tcf7 mutation (29 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal digestive system morphology ( J:185753 )
• tamoxifen-treatment results in the same defects as in Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle Tg(Vil-cre/ERT2)23Syr mice
abnormal digestive system physiology ( J:185753 )
• tamoxifen-treatment results in the same defects as in Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle Tg(Vil-cre/ERT2)23Syr mice




Genotype
MGI:5314534
cn4
Allelic
Composition		 Hesx1tm1(cre)Jpmb/Hesx1+
Tcf7l1tm1Efu/Tcf7l1tm2Efu
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)
Tcf7l1tm1Efu mutation (0 available); any Tcf7l1 mutation (83 available)
Tcf7l1tm2Efu mutation (0 available); any Tcf7l1 mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
microphthalmia ( J:181005 )
• unilateral in some mice
• bilateral in some mice
anophthalmia ( J:181005 )
• unilateral in some mice
• bilateral in some mice

nervous system
decreased forebrain size ( J:181005 )
• severe truncation in some mice




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory