Phenotypes associated with this allele

• Allele Symbol: Tg(Sry)2Ei
• Allele Name: transgene insertion 2, Eva M Eicher
• Allele ID: MGI:3041982
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	X/Sry^dl1Rlb Tg(Sry)2Ei/0	involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1	MGI:3043703
cx2	X/Del(Y)1PsbSry^dl1Rlb Tg(Sry)2Ei/0	involves: 129S6/SvEvTac * MF1	MGI:3043585
cx3	X/Del(Y)1H Tg(Sry)2Ei/0	involves: C57BL/6Ei * MF1	MGI:3043701
cx4	X/Del(Y)1H Tg(Sry)2Ei/0	involves: MF1	MGI:3043702
tg5	Tg(Sry)2Ei/0	C57BL/6JEi-Chr Y^AKR	MGI:3043670

Genotype
MGI:3043703

cx1

• Allelic Composition: X/Sry^dl1Rlb; Tg(Sry)2Ei/0
• Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

primary sex reversal ( J:89312 )

• chromosomal males that would have developed as fertile females develop as males

Genotype
MGI:3043585

cx2

• Allelic Composition: X/Del(Y)1PsbSry^dl1Rlb; Tg(Sry)2Ei/0
• Genetic Background: involves: 129S6/SvEvTac * MF1

reproductive system

abnormal acrosome morphology ( J:89616 )

♂ • all sperm exhibit defects in acrosomal morphology

male infertility ( J:89616 )

♂

cellular

abnormal acrosome morphology ( J:89616 )

♂ • all sperm exhibit defects in acrosomal morphology

Genotype
MGI:3043701

cx3

• Allelic Composition: X/Del(Y)1H; Tg(Sry)2Ei/0
• Genetic Background: involves: C57BL/6Ei * MF1

reproductive system

primary sex reversal ( J:46791 )

• chromosomal females carrying this transgene develop as males

• chromosomal males that would have developed as sex-reversed females develop as males in mutants carrying this transgene

infertility ( J:46791 )

• sex reversed XX males are sterile

Genotype
MGI:3043702

cx4

• Allelic Composition: X/Del(Y)1H; Tg(Sry)2Ei/0
• Genetic Background: involves: MF1

reproductive system

abnormal sperm head morphology ( J:89312 )

• sex-reversal rescued mutant males show an increase in sperm with slightly or grossly abnormal heads compared to other sex-reversal rescued mice hemizygous for Sry^dl1Rob

primary sex reversal ( J:89312 )

• chromosomal males that would have developed as fertile females develop as males

• chromosomal females carrying this transgene develop as males

infertility ( J:89312 )

• sex reversed XX males are sterile

cellular

abnormal sperm head morphology ( J:89312 )

• sex-reversal rescued mutant males show an increase in sperm with slightly or grossly abnormal heads compared to other sex-reversal rescued mice hemizygous for Sry^dl1Rob

Genotype
MGI:3043670

tg5

• Allelic Composition: Tg(Sry)2Ei/0
• Genetic Background: C57BL/6JEi-Chr Y^AKR

reproductive system

primary sex reversal ( J:71077 )

• chromosomal females carrying this transgene develop as males

infertility ( J:71077 )

• chromosomal females develop as males but are sterile due to the presence of 2 X chromosomes and the absence of a Y chromosome