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Del(Y)1H
Spontaneous Allele Detail
Summary
Symbol: Del(Y)1H
Name: deletion, Chr Y, 1 Harwell
MGI ID: MGI:3043691
Synonyms: Del1Ct, Yd-1, Yd1
Gene: Del(Y)1H  Location: unknown  Genetic Position: ChrY, Syntenic
Mutation
origin
Strain of Origin:  BALB/cJToxCrcH and RIII
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intergenic deletion
  Del(Y)1H involves 1 genes/genome features (Rbmyc) View all
 
Mutation detailsThis Y Chr deletion resulted from asymmetric recombination during male meiosis between the short arm of a Y Chr (Yp) of BALB/c origin and an X Chr carrying Tp(Y)1CtSxr-a. Whereas Sry (sex determining region of Chr Y) and 16 other single-copy genes and pseudogenes on Yp appear intact by Southern blot or PCR analysis, the unequal exchange resulted in deletion of 3-4 Mb, including 90% of the Rbmy (RNA binding motif protein, Y Chr) repeat sequence family, which resides between Sry and the centromere and normally comprises at least 50 copies. Sry transcripts are undetectable by semiquantitative RT-PCR analysis of RNA from the genital ridges of 11.5 day post coitus (dpc) XYDel(Y)1H and XXYDel(Y)1H embryos; in contrast, transcripts from Kdm5d, which maps distal to Sry between Zfy1 and Zfy2, are similarly abundant in XYDel(Y)2H and XY 11.5 dpc genital ridges. (J:15425, J:29526, J:46791)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(Y)1H Mutation:  0 strains or lines available
References
Original:  J:15425 Capel B, et al., Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal. Nat Genet. 1993 Nov;5(3):301-7
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory