Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1h2tm1Djm mutation
(3 available);
any
Nr1h2 mutation
(26 available)
|
|
|
integument
|
• the epidermis of mutant mice is thinner with fewer proliferating cells in the basal layer compared to wild-type littermates
• treatment with oxysterol does not result in thickening of the epidermis unlike in wild-type littermates and Nr1h3tm1Djm homozygotes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1h2tm1Djm mutation
(3 available);
any
Nr1h2 mutation
(26 available)
|
|
|
mortality/aging
|
• mice succumb to infection of Listeria monocytogenes 2-3 days earlier than controls
|
|
• occasionally mothers fail to expulse pups from uterine horns leading rarely to death
|
immune system
|
• mice succumb to infection of Listeria monocytogenes 2-3 days earlier than controls
|
reproductive system
|
• proliferation of male germ cells is significantly decreased compared to controls
|
|
• Sertoli cells have vacuoles containing cholesterol esters
|
|
• vacuoles filled with cholesterol esters are present within the myoctes
• concentration of cholesterol esters are about 25-fold higher at 3 and 12 months of age
|
|
• occasionally mothers fail to expulse pups from uterine horns leading to hind-limb paralysis and rarely to death
|
|
• myometrium muscle has lower amplitudes of contraction compared to controls in response to pharmacological levels of oxytocin
|
endocrine/exocrine glands
|
• Sertoli cells have vacuoles containing cholesterol esters
|
behavior/neurological
|
• occasionally mothers fail to expulse pups from uterine horns leading to hind-limb paralysis and rarely to death
|
muscle
|
• myometrium (uterus) muscle has lower amplitudes of contraction compared to controls in response to pharmacological levels of oxytocin
|
cellular
|
• proliferation of male germ cells is significantly decreased compared to controls
|
homeostasis/metabolism
liver/biliary system
|
• hepatic cholesterol levels are 4-fold higher than controls in mice fed a 0.2% cholesterol diet
|
mortality/aging
|
• mice die between 60 and 90 days of age from neurodegenerative disease, which is significantly faster than Npc1 mutants on a wild-type background
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1h2tm1Djm mutation
(3 available);
any
Nr1h2 mutation
(26 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation
(6 available)
|
|
|
nervous system
|
• a significant increase in cortical the Abeta1-40 plaque number is seen in mice at 32 weeks of age compared transgenic mice on a wild-type background
• plaques are also increased in size
• there is also a significant increase in Abeta1-42 plaque number at this age
|
homeostasis/metabolism
mortality/aging
|
• all mice die when given 104 CFU of Listeria monocytogenes compared to all wild-type controls surviving
• at higher doses mice succumb to the infection 2-3 days earlier than controls
|
|
• occasionally mothers fail to expulse pups from uterine horns leading rarely to death
|
reproductive system
|
• proliferation of male germ cells is significantly decreased compared to controls
|
|
• vacuoles filled with cholesterol esters are present within the myoctes
• concentration of cholesterol esters are 32-fold higher at 3 months of age and 66-fold higher at 12 months of age
|
|
• 20-30% of 5.5 month old males have abnormal tubules with cellular aggregates clumping in the middle without any spermatozoa
• by 10 months of age, most tubules are empty without any spermatozoa
|
|
• Sertoli cells have vacuoles filled with cholesterol esters within in them
|
|
• by 12 months of age, seminiferous tubules are degraded from deposits cholesterol
|
|
• Leydig cells in mice 3.5 months of age are enlarged
|
|
• a significant decline in testis weight is noted starting at 9 weeks of age
|
|
• as mice age, testis lose weight and morphology of the glands becomes becomes disrupted by cholesterol deposits
|
|
• occasionally mothers fail to expulse pups from uterine horns leading to hind-limb paralysis and rarely to death
|
|
• myometrium muscle has lower amplitudes of contraction compared to controls in response to pharmacological levels of oxytocin
|
|
• apoptosis of germ cells within seminiferous tubules is more than double that of controls
• ratio of proliferating/apoptotic male germ cells is significantly decreased compared to controls
|
|
• male mice start exhibiting fertility problems around 5 months of age with complete loss of fertility occurring by 7 months of age
• the fertility problems exhibited at 5 months of age include only 55% of mated females exhibiting vaginal plugs and dramatic reductions in litter size
|
homeostasis/metabolism
behavior/neurological
|
• occasionally mothers fail to expulse pups from uterine horns leading to hind-limb paralysis and rarely to death
|
immune system
|
• peritoneal macrophages have a 2.7-fold increase in free cholesterol and a
2.4-fold increase in total cholesterol
|
|
• all mice die when given 104 CFU of Listeria monocytogenes compared to all wild-type controls surviving
• at higher doses mice succumb to the infection 2-3 days earlier than controls
|
muscle
|
• myometrium (uterus) muscle has lower amplitudes of contraction compared to controls in response to pharmacological levels of oxytocin
|
hematopoietic system
|
• peritoneal macrophages have a 2.7-fold increase in free cholesterol and a
2.4-fold increase in total cholesterol
|
|
• when bone marrow is transferred into irradiated Apoe-null mice, bone marrow cells fail to lower total serum cholesterol levels as wild-type bone marrow cells do
• aortas from these mice have 3- to 8-fold more atherosclerotic lesions than Apoe-null mice receiving wild-type bone marrow
• increased atherosclerotic lesions are also observed when mutant bone marrow is transferred into LDLR-null mice
• spleens of recipient LDLR-null mice are also enlarged
|
endocrine/exocrine glands
|
• 20-30% of 5.5 month old males have abnormal tubules with cellular aggregates clumping in the middle without any spermatozoa
• by 10 months of age, most tubules are empty without any spermatozoa
|
|
• Sertoli cells have vacuoles filled with cholesterol esters within in them
|
|
• by 12 months of age, seminiferous tubules are degraded from deposits cholesterol
|
|
• Leydig cells in mice 3.5 months of age are enlarged
|
|
• a significant decline in testis weight is noted starting at 9 weeks of age
|
|
• as mice age, testis lose weight and morphology of the glands becomes becomes disrupted by cholesterol deposits
|
cellular
|
• apoptosis of germ cells within seminiferous tubules is more than double that of controls
• ratio of proliferating/apoptotic male germ cells is significantly decreased compared to controls
|
|
• proliferation of male germ cells is significantly decreased compared to controls
|