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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pomctm1Sora
targeted mutation 1, S O'Rahilly
MGI:3040514
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pomctm1Sora/Pomctm1Sora involves: 129S2/SvHsd * 129S6/SvEvTac MGI:3041643
ht2
 		Pomctm1Sora/Pomc+ involves: 129S2/SvHsd * 129S6/SvEvTac MGI:3041651
cx3
 		a/A
Pomctm1Sora/Pomctm1Sora 		involves: 129S6/SvEvTac MGI:3805940
cx4
 		a/A
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/? 		involves: 129S6/SvEvTac * C57BL/6Ha MGI:3805942
cx5
 		a/a
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/? 		involves: 129S6/SvEvTac * C57BL/6Ha MGI:3805943


Genotype
MGI:3041643
hm1
Allelic
Composition		 Pomctm1Sora/Pomctm1Sora
Genetic
Background		 involves: 129S2/SvHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Sora mutation (0 available); any Pomc mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:89244 )
• lighter ventral coat color than that of wild-type

behavior/neurological

growth/size/body
obese ( J:89244 )
• increased body weight, relative to controls, when on standard lab diet (4.5% fat)
• significantly higher fat and lean tissue mass relative to controls
• attenuated affect on both food intake and weight loss in response to leptin; observed in older, obese, mice but not in younger, nonobese mice
• responses to both acute anoretic and chronic administration of peptide-YY3-36 were similar to those of wild-type
increased susceptibility to diet-induced obesity ( J:89244 )
• a high fat diet augmented the obese phenotype

homeostasis/metabolism
increased susceptibility to diet-induced obesity ( J:89244 )
• a high fat diet augmented the obese phenotype
decreased circulating corticosterone level ( J:89244 )
• corticosterone was undetectable
decreased oxygen consumption ( J:89244 )
• while oxygen consumption was increased in absolute terms, when corrected for total body mass, resting oxygen consumption was reduced relative to controls

integument
diluted coat color ( J:89244 )
• lighter ventral coat color than that of wild-type

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
obesity DOID:9970 OMIM:601665
 J:89244




Genotype
MGI:3041651
ht2
Allelic
Composition		 Pomctm1Sora/Pomc+
Genetic
Background		 involves: 129S2/SvHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Sora mutation (0 available); any Pomc mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:89244 )
• lighter ventral coat color than that of wild-type

homeostasis/metabolism
decreased circulating corticosterone level ( J:89244 )
• decreased, in spite of normal adrenal gland structure

growth/size/body
increased susceptibility to diet-induced obesity ( J:89244 )

integument
integument phenotype ( J:89244 )
N
• normal pigmentation
diluted coat color ( J:89244 )
• lighter ventral coat color than that of wild-type




Genotype
MGI:3805940
cx3
Allelic
Composition		 a/A
Pomctm1Sora/Pomctm1Sora
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A mutation (19 available); any a mutation (463 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a slightly more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (0.30) than in agouti controls (0.19)

integument
yellow coat color ( J:129904 )
• mice have a slightly more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (0.30) than in agouti controls (0.19)




Genotype
MGI:3805942
cx4
Allelic
Composition		 a/A
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6Ha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A mutation (19 available); any a mutation (463 available)
Mc1re mutation (4 available); any Mc1r mutation (43 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (19 available)
Tg(MC1R)1Jkn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a much more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (2.00) than in agouti controls (0.19)

integument
yellow coat color ( J:129904 )
• mice have a much more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (2.00) than in agouti controls (0.19)




Genotype
MGI:3805943
cx5
Allelic
Composition		 a/a
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6Ha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Mc1re mutation (4 available); any Mc1r mutation (43 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (19 available)
Tg(MC1R)1Jkn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a much more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (1.74) than in controls (0.20)

integument
yellow coat color ( J:129904 )
• mice have a much more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (1.74) than in controls (0.20)




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory