Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha2tm1Jrui mutation
(2 available);
any
Epha2 mutation
(96 available)
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cardiovascular system
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• endothelial cells fail to assemble into capillary-like structure (vascular assembly) and to migrate in response to ephrin A1 (Efna1) in vitro
• mutants show impaired ephrin A1-induced angiogenesis in vivo
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neoplasm
N |
• phenotypes are relative to the control KPC (KrasG12D/+, p53R172H/+, Pdx1-Cre) PDAC (pancreatic adenocarcinoma) model mice
• size of PDAC primary tumors same as control
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• significantly reduced number of detectable PDAC metastases to liver, lung and other tissues
• reduced migration of PDAC cells in vitro
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mortality/aging
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• survival reduced compared to control
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