All Phenotypes Ptprv<tm1Asmi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprv^tm1Asmi/Ptprv^tm1Asmi	involves: 129P2/OlaHsd	MGI:3763087
hm2	Ptprv^tm1Asmi/Ptprv^tm1Asmi	involves: 129P2/OlaHsd * C57BL/6J	MGI:4360507
ht3	Ptprv^tm1Asmi/Ptprv⁺	involves: 129P2/OlaHsd * MF1	MGI:3040513
cx4	Atf4^tm1Tow/Atf4⁺ Ptprv^tm1Asmi/Ptprv⁺	either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss)	MGI:4360508
cx5	Lep^ob/Lep^ob Ptprv^tm1Asmi/Ptprv^tm1Asmi	involves: 129P2/OlaHsd * C57BL/10J	MGI:3837372
cx6	Lep^ob/Lep^ob Ptprv^tm1Asmi/Ptprv⁺	involves: 129P2/OlaHsd * C57BL/10J	MGI:3837373

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:126780 )

• one of mouse died following treatment with streptozotocin compared to 3 of 7 similarly treated wild-type mice

reproductive system

reproductive system phenotype ( J:170888 )

N	• male germ cell proliferation is normal

abnormal male germ cell apoptosis ( J:170888 )

• number of germ cells is decreased 2-fold

increased seminal vesicle weight ( J:170888 )

• worsening with time

enlarged testis ( J:170888 )

• at 3 months of age

increased Leydig cell number ( J:170888 )

increased testis weight ( J:170888 )

• at 3 months of age

increased sperm number ( J:170888 )

• sperm count is increased compared to in wild-type mice

• worsening with time

increased epididymis weight ( J:170888 )

• worsening with time

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:126780 )

• mice are resistant to diet-induced obesity and show no evidence of glucose tolerance or insulin sensitivity

decreased circulating glucose level ( J:126780 )

• following injection with streptozotocin, surviving mice have glucose serum levels less than 250 mg/dl compared to above 500 mg/dl in similarly treated wild-type mice

increased circulating testosterone level ( J:170888 )

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:126780 )

• one of mouse died following treatment with streptozotocin compared to 3 of 7 similarly treated wild-type mice

growth/size/body

growth/size/body region phenotype ( J:126780 )

N	• when injected with gold thioglucose, mice fail to develop obesity, have fat pads, and serum triglyceride levels similar to in untreated mice with no evidence of glucose tolerance or insulin sensitivity

decreased susceptibility to diet-induced obesity ( J:126780 )

• mice are resistant to diet-induced obesity and show no evidence of glucose tolerance or insulin sensitivity

endocrine/exocrine glands

increased seminal vesicle weight ( J:170888 )

• worsening with time

enlarged testis ( J:170888 )

• at 3 months of age

increased Leydig cell number ( J:170888 )

increased testis weight ( J:170888 )

• at 3 months of age

cellular

abnormal male germ cell apoptosis ( J:170888 )

• number of germ cells is decreased 2-fold

Allelic Composition	Ptprv^tm1Asmi/Ptprv^tm1Asmi
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprv^tm1Asmi mutation (0 available); any Ptprv mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:152695 )

increased circulating insulin level ( J:152695 )

endocrine/exocrine glands

increased pancreatic beta cell proliferation ( J:152695 )

• beta cell proliferation is increased compared to in wild-type mice

cellular

increased pancreatic beta cell proliferation ( J:152695 )

• beta cell proliferation is increased compared to in wild-type mice

Allelic Composition	Ptprv^tm1Asmi/Ptprv⁺
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprv^tm1Asmi mutation (0 available); any Ptprv mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89221 )

• mice were viable, fertile, and showed no overt anatomical abnormalities

Allelic Composition	Atf4^tm1Tow/Atf4⁺ Ptprv^tm1Asmi/Ptprv⁺
Genetic Background	either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4^tm1Tow mutation (1 available); any Atf4 mutation (21 available)
Ptprv^tm1Asmi mutation (0 available); any Ptprv mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:152695 )

increased circulating insulin level ( J:152695 )

endocrine/exocrine glands

increased pancreatic beta cell proliferation ( J:152695 )

• beta cell proliferation is increased compared to in wild-type mice

cellular

increased pancreatic beta cell proliferation ( J:152695 )

• beta cell proliferation is increased compared to in wild-type mice

Allelic Composition	Lep^ob/Lep^ob Ptprv^tm1Asmi/Ptprv^tm1Asmi
Genetic Background	involves: 129P2/OlaHsd * C57BL/10J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lep^ob mutation (5 available); any Lep mutation (19 available)
Ptprv^tm1Asmi mutation (0 available); any Ptprv mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:145998 )

• mice exhibit low blood glucose levels that are less than in Lep^ob homozygotes until 8 weeks of age

increased circulating insulin level ( J:145998 )

• mice exhibit elevated serum insulin levels that are 2-fold higher than in Lep^ob homozygotes

improved glucose tolerance ( J:145998 )

• mice exhibit improved glucose tolerance compared to in Lep^ob homozygotes

• however, insulin sensitivity is the same as in Lep^ob homozygotes

Allelic Composition	Lep^ob/Lep^ob Ptprv^tm1Asmi/Ptprv⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/10J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:145998 )

• mice exhibit elevated serum insulin levels that are higher than in Lep^ob homozygotes

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